The role of vitamin D deficiency in children with recurrent wheezing-clinical significance
Author(s)
Feketea, Gavriela
Bocsan, Corina I
Stanciu, Luminita Aurelia
Buzoianu, Anca Dana
Zdrenghea, Mihnea Tudor
Type
Journal Article
Abstract
Recurrent wheezing (RW) in infancy is one of the most frequent reasons for parents to consult health care providers and creates a significant global burden. Clinical course of RW is difficult to predict, also which infants will progress to asthma, since no valid biomarkers have been established. Identification of those infants with RW who are at risk of further recurrences and/or severe acute respiratory tract infection (ARTI) could help pediatricians to improve their therapeutic decisions. Increasing research interest is focused on the extra-skeletal actions of vitamin D (VD) and the clinical impact of VD insufficiency/deficiency. As VD deficiency could be a risk factor for causing RW in children, measurement of their serum level of 25-hydroxycholecalciferol [25(OH)D] is recommended. In the case of deficiency, VD administration is recommended in age-appropriate doses for at least 6 weeks, until achievement of normal blood 25(OH)D level, followed by supplementation as long as exposure to sun is inadequate. Higher doses of VD given in an attempt to prevent asthma development appear to be of no additional benefit. In children with severe ARTI, VD level is recommended to be assess.
Date Issued
2020-06-30
Date Acceptance
2020-05-26
Citation
Frontiers in Pediatrics, 2020, 8, pp.1-7
ISSN
2296-2360
Publisher
Frontiers Media
Start Page
1
End Page
7
Journal / Book Title
Frontiers in Pediatrics
Volume
8
Copyright Statement
© 2020 Feketea, Bocsan, Stanciu, Buzoianu and Zdrenghea. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
License URL
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000553007900001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Pediatrics
vitamin D
25(OH)D
vitamin D receptor (VDR)
recurrent wheezing
asthma
respiratory allergies
RESPIRATORY-TRACT INFECTIONS
SERUM 25-HYDROXYVITAMIN D
D SUPPLEMENTATION
IMMUNE-RESPONSE
ASTHMA
HEALTH
CELLS
TRIAL
RISK
Publication Status
Published
Article Number
ARTN 344
Date Publish Online
2020-06-30