Bile acids and the metabolic syndrome
File(s)
Accepted version
Author(s)
McGlone, Emma Rose
Bloom, Stephen R
Type
Journal Article
Abstract
Bile acids have important roles in the regulation of lipid, glucose and energy metabolism. Metabolic diseases linked to obesity, including type 2 diabetes mellitus and non-alcoholic fatty liver disease, are associated with dysregulation of bile acid homeostasis. Here, the basic chemistry and regulation of bile acids as well as their metabolic effects will be reviewed. Changes in circulating bile acids associated with obesity and related diseases will be reviewed. Finally, pharmaceutical manipulation of bile acid homeostasis as therapy for metabolic diseases will be outlined.
Date Issued
2019-05-01
Date Acceptance
2018-11-15
Citation
Annals of Clinical Biochemistry, 2019, 56 (3), pp.326-337
ISSN
1758-1001
Publisher
SAGE Publications
Start Page
326
End Page
337
Journal / Book Title
Annals of Clinical Biochemistry
Volume
56
Issue
3
Copyright Statement
© 2019 The Author(s). The final, definitive version of this paper has been published in Annals of Clinical Biochemistry by Sage Publications Ltd. All rights reserved. It is available at: https://dx.doi.org/10.1177/0004563218817798
Sponsor
National Institute for Health Research
National Institute for Health Research
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/30453753
Grant Number
NF-SI-0507-10337
NF-SI-0513-10080
Subjects
Bile acids
Takeda G-protein coupled receptor 5
farnesoid X receptor
metabolic syndrome
non-alcoholic fatty liver disease
type 2 diabetes mellitus
Publication Status
Published
Coverage Spatial
England
Date Publish Online
2019-03-04