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The role of seminal oxidative stress in recurrent pregnancy loss
File(s)
antioxidants-12-00723.pdf (1.14 MB)
Published version
Author(s)
Davies, Rhianna
Jayasena, Channa N
Rai, Raj
Minhas, Suks
Type
Journal Article
Abstract
Recurrent pregnancy loss is a distressing condition affecting 1-2% of couples. Traditionally investigations have focused on the female, however more recently researchers have started to explore the potential contribution of the male partner. Seminal reactive oxygen species have a physiological function in male reproduction but in excess are suspected to generate structural and functional damage to the sperm. Evidence is mounting to support an association between elevated seminal reaction oxygen species and recurrent pregnancy loss. Studies suggest that the rates of sperm DNA damage are higher in the male partners of women affected by recurrent pregnancy loss compared with unaffected men. However, the available pool of data is conflicting, and interpretation is limited by the recent change in nomenclature and the heterogeneity of study methodologies. Furthermore, investigation into the effects of oxidative stress on the epigenome show promise. The value of antioxidant therapy in the management of recurrent pregnancy loss currently remains unclear.
Date Issued
2023-03-15
Date Acceptance
2023-03-07
Citation
Antioxidants, 2023, 12 (3), pp.1-12
URI
URL
DOI
ISSN
2076-3921
Publisher
MDPI AG
Start Page
1
End Page
12
Journal / Book Title
Antioxidants
Volume
12
Issue
3
Copyright Statement
Copyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and
conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/36978971
PII: antiox12030723
Subjects
antioxidants
reactive oxygen species
recurrent pregnancy loss
ROS
sperm DNA damage
Publication Status
Published
Coverage Spatial
Switzerland
Article Number
723
Date Publish Online
2023-03-15