Anhedonia in combat veterans with penetrating head injury.
File(s)
Author(s)
Type
Journal Article
Abstract
Anhedonia is a common symptom following traumatic brain injury. The neural basis of anhedonia is poorly understood, but believed to involve disturbed reward processing, rather than the loss of sense of pleasure. This analysis was undertaken to determine if injury to specific regions of prefrontal cortex (PFC) result in anhedonia. A CT-based lesion analysis was undertaken in 192 participants of the Vietnam Head Injury Study, most with penetrating head injury. Participants were divided into left and right ventrolateral prefrontal, bilateral ventromedial prefrontal, and other injury locations. Anhedonia was measured by self-report in each group using the four-item anhedonia subscale score of the Beck Depression Inventory-II. Individuals with right ventrolateral injury reported greater severity of anhedonia compared to those with injury in the left ventrolateral region. These findings support an association between injury in the right ventrolateral PFC and anhedonia.
Date Issued
2015-06-07
Date Acceptance
2015-05-26
Citation
Brain Imaging and Behavior, 2015, 9 (3), pp.456-460
ISSN
1931-7565
Publisher
Springer
Start Page
456
End Page
460
Journal / Book Title
Brain Imaging and Behavior
Volume
9
Issue
3
Copyright Statement
© Springer Science+Business Media New York (outside the USA) 2015. The final publication is available at Springer via https://dx.doi.org/10.1007/s11682-015-9414-4
Publication Status
Published