Current and future perspectives on pregnancy and lactation-associated osteoporosis
File(s)
Published version
Author(s)
Nataliya, Gak
Abbara, Ali
Dhillo, waljit
Keen, Richard
Comninos, Alexander N
Type
Journal Article
Abstract
Normal pregnancy and lactation have a marked physiological impact on maternal bone metabolism. This impact is usually temporary and reversible, but some women sustain fragility fractures whilst pregnant or lactating, termed pregnancy and lactation-associated osteoporosis (PLO). These fractures have severe negative consequences on their quality of life, at what is a crucial stage in a mother’s life. Identifiable risk factors include a low body mass index (BMI), reduced physical activity during adolescence, a strong family history of osteoporosis, and genetic variations in the LRP5 and WNT1 genes. However, due to the rarity of PLO and the limited awareness surrounding it, there has been slow progress in understanding its pathophysiology and identifying the most effective treatments. Indeed, the data available primarily originates from observational and case studies, resulting in little clear guidance on a comprehensive and multidisciplinary approach. This mini-review synthesises the latest data on incidence, pathophysiology, and management in PLO, providing current and future perspectives and highlights the need for evidence-based guidelines to improve both short-term and long-term outcomes for women with PLO.
Date Issued
2024-12-05
Date Acceptance
2024-11-11
Citation
Frontiers in Endocrinology, 2024, 15
ISSN
1664-2392
Publisher
Frontiers Media S.A.
Journal / Book Title
Frontiers in Endocrinology
Volume
15
Copyright Statement
© 2024 Gak, Abbara, Dhillo, Keen and
Comninos. This is an open-access article
distributed under the terms of the Creative
Commons Attribution License (CC BY). The
use, distribution or reproduction in other
forums is permitted, provided the original
author(s) and the copyright owner(s) are
credited and that the original publication in
this journal is cited, in accordance with
accepted academic practice. No use,
distribution or reproduction is permitted
which does not comply with these terms
Comninos. This is an open-access article
distributed under the terms of the Creative
Commons Attribution License (CC BY). The
use, distribution or reproduction in other
forums is permitted, provided the original
author(s) and the copyright owner(s) are
credited and that the original publication in
this journal is cited, in accordance with
accepted academic practice. No use,
distribution or reproduction is permitted
which does not comply with these terms
License URL
Identifier
https://doi.org/10.3389/fendo.2024.1494965
Publication Status
Published
Article Number
1494965
Date Publish Online
2024-12-05