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De novo lipogenesis in the liver in health and disease: more than just a shunting yard for glucose
File(s)
Author(s)
Sanders, Francis WB
Griffin, Julian L
Type
Journal Article
Abstract
Hepatic de novo lipogenesis (DNL) is the biochemical process of synthesising fatty acids from acetyl-CoA subunits that are produced from a number of different pathways within the cell, most commonly carbohydrate catabolism. In addition to glucose which most commonly supplies carbon units for DNL, fructose is also a profoundly lipogenic substrate that can drive DNL, important when considering the increasing use of fructose in corn syrup as a sweetener. In the context of disease, DNL is thought to contribute to the pathogenesis of non-alcoholic fatty liver disease, a common condition often associated with the metabolic syndrome and consequent insulin resistance. Whether DNL plays a significant role in the pathogenesis of insulin resistance is yet to be fully elucidated, but it may be that the prevalent products of this synthetic process induce some aspect of hepatic insulin resistance.
Date Issued
2016-05-01
Date Acceptance
2015-01-20
Citation
Biological Reviews of the Cambridge Philosophical Society, 2016, 91 (2), pp.452-468
URI
DOI
ISSN
1464-7931
Publisher
Wiley
Start Page
452
End Page
468
Journal / Book Title
Biological Reviews of the Cambridge Philosophical Society
Volume
91
Issue
2
Copyright Statement
© 2015 The Authors. Biological Reviews published by John Wiley & Sons Ltd on behalf of Cambridge Philosophical Society.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/25740151
Subjects
de novo lipogenesis (DNL)
fructose
liver
non-alcoholic fatty liver disease (NAFLD)
selective insulin resistance
Animals
Blood Glucose
Diabetes Mellitus, Type 2
Glucose
Humans
Lipogenesis
Liver Diseases
Prediabetic State
Publication Status
Published
Coverage Spatial
England
Date Publish Online
2015-03-04