Waterborne Elizabethkingia meningoseptica in adult critical care
File(s)
Author(s)
Type
Journal Article
Abstract
Elizabethkingia meningoseptica is an infrequent colonizer of the respiratory tract; its pathogenicity is uncertain. In the context of a 22-month outbreak of E. meningoseptica acquisition affecting 30 patients in a London, UK, critical care unit (3% attack rate) we derived a measure of attributable morbidity and determined whether E. meningoseptica is an emerging nosocomial pathogen. We found monomicrobial E. meningoseptica acquisition (n = 13) to have an attributable morbidity rate of 54% (systemic inflammatory response syndrome >2, rising C-reactive protein, new radiographic changes), suggesting that E. meningoseptica is a pathogen. Epidemiologic and molecular evidence showed acquisition was water-source–associated in critical care but identified numerous other E. meningoseptica strains, indicating more widespread distribution than previously considered. Analysis of changes in gram-negative speciation rates across a wider London hospital network suggests this outbreak, and possibly other recently reported outbreaks, might reflect improved diagnostics and that E. meningoseptica thus is a pseudo-emerging pathogen.
Date Issued
2016-01-01
Date Acceptance
2016-01-01
Citation
Emerging Infectious Diseases, 2016, 22 (1), pp.9-17
ISSN
1080-6059
Publisher
Centers for Disease Control and Prevention
Start Page
9
End Page
17
Journal / Book Title
Emerging Infectious Diseases
Volume
22
Issue
1
Copyright Statement
Emerging Infectious Diseases is published by the Centers for Disease Control and Prevention, a U.S. Government agency. Therefore, all materials published in Emerging Infectious Diseases are in the public domain and can be used without permission. Proper citation, however, is required.
Sponsor
Imperial College Healthcare NHS Trust- BRC Funding
National Institute of Health Research Imperial Biomedical Research Centre
Grant Number
RDA02
WMNF_P46472
Subjects
Science & Technology
Life Sciences & Biomedicine
Immunology
Infectious Diseases
DESORPTION IONIZATION-TIME
FLIGHT MASS-SPECTROMETRY
CHRYSEOBACTERIUM-MENINGOSEPTICUM
EMERGING PATHOGEN
IDENTIFICATION
BACTEREMIA
OUTBREAK
EPIDEMIOLOGY
INFECTIONS
DIVERSITY
Chryseobacterium meningosepticum
Elizabethkingia meningoseptica
Flavobacterium meningosepticum
Matrix-assisted laser desorption/ionization time-of-flight
United Kingdom
adults
antimicrobial drug resistance
intensive care
water
Microbiology
1108 Medical Microbiology
1117 Public Health And Health Services
1103 Clinical Sciences
Publication Status
Published