Dynamic Inversion Time for Improved 3D Late Gadolinium Enhancement Imaging in Patients with Atrial Fibrillation
File(s)Keegan_dynamicTI.pdf (2.27 MB)
Published version
Author(s)
Type
Journal Article
Abstract
Purpose—High resolution 3D late gadolinium enhancement (LGE) imaging is performed with
single R-wave gating to minimise lengthy acquisition durations. In patients with atrial fibrillation
(AF), heart rate variability results in variable magnetisation recovery between sequence repeats
and image quality is often poor. In this study, we implemented and tested a dynamic inversion
time scheme designed to reduce sequence sensitivity to heart rate variations.
Methods—An inversion-prepared 3D segmented gradient echo sequence was modified so that
the inversion time (TI) varied automatically from beat-to-beat (dynamic-TI) based on the time
since the last sequence repeat. 3D LGE acquisitions were performed in 17 patients prior to RF
ablation of persistent AF both with and without dynamic-TI. Qualitative image quality scores,
blood signal-to-ghosting ratios (SGRs) and blood-myocardium contrast-to-ghosting ratios (CGRs)
were compared.
Results—Image quality scores were higher with dynamic-TI than without (2.2 +/− 0.9 versus 1.8
+/− 1.1, p = 0.008) as were blood-myocardium CGRs (13.8 +/− 7.6 versus 8.3 +/− 6.1, p = 0.003)
and blood SGRs (19.6 +/− 8.5 versus 13.1 +/− 8.0, p = 0.003).
Conclusions—The dynamic-TI algorithm improves image quality of 3D LGE imaging in this
difficult patient population by reducing the sequence sensitivity to RR interval variations.
single R-wave gating to minimise lengthy acquisition durations. In patients with atrial fibrillation
(AF), heart rate variability results in variable magnetisation recovery between sequence repeats
and image quality is often poor. In this study, we implemented and tested a dynamic inversion
time scheme designed to reduce sequence sensitivity to heart rate variations.
Methods—An inversion-prepared 3D segmented gradient echo sequence was modified so that
the inversion time (TI) varied automatically from beat-to-beat (dynamic-TI) based on the time
since the last sequence repeat. 3D LGE acquisitions were performed in 17 patients prior to RF
ablation of persistent AF both with and without dynamic-TI. Qualitative image quality scores,
blood signal-to-ghosting ratios (SGRs) and blood-myocardium contrast-to-ghosting ratios (CGRs)
were compared.
Results—Image quality scores were higher with dynamic-TI than without (2.2 +/− 0.9 versus 1.8
+/− 1.1, p = 0.008) as were blood-myocardium CGRs (13.8 +/− 7.6 versus 8.3 +/− 6.1, p = 0.003)
and blood SGRs (19.6 +/− 8.5 versus 13.1 +/− 8.0, p = 0.003).
Conclusions—The dynamic-TI algorithm improves image quality of 3D LGE imaging in this
difficult patient population by reducing the sequence sensitivity to RR interval variations.
Date Issued
2015-01-16
Date Acceptance
2014-02-03
Citation
Magnetic Resonance in Medicine, 2015, 73 (2), pp.646-654
ISSN
1522-2594
Publisher
Wiley
Start Page
646
End Page
654
Journal / Book Title
Magnetic Resonance in Medicine
Volume
73
Issue
2
Copyright Statement
This is the peer reviewed version of the following article: Keegan, J., Gatehouse, P. D., Haldar, S., Wage, R., Babu-Narayan, S. V. and Firmin, D. N. (2015), Dynamic inversion time for improved 3D late gadolinium enhancement imaging in patients with atrial fibrillation. Magn Reson Med, 73: 646–654, which has been published in final form at https://dx.doi.org/10.1002/mrm.25190. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.
Subjects
Science & Technology
Life Sciences & Biomedicine
Radiology, Nuclear Medicine & Medical Imaging
late gadolinium enhancement imaging
3D
arrhythmia
CATHETER ABLATION
PULMONARY VEINS
MANAGEMENT
FIBROSIS
SCAR
MRI
ASSOCIATION
EXTENT
Publication Status
Published