Oncometabolite Tinkers with Genome Folding, Boosting Oncogene Expression.
File(s)IDH spotlight.pdf (3.39 MB)
Accepted version
Author(s)
Ing-Simmons, E
Merkenschlager, M
Type
Journal Article
Abstract
A recent article makes a compelling case for a new mechanism by which heterozygous mutations in isocitrate dehydrogenases (IDH1/2) - implicated in cancer - undermine gene regulation. 2-Hydroxyglutarate (2HG) produced by mutant IDH alters the binding of the chromosomal organizer protein CTCF, disrupting the spatial and regulatory organization of the genome.
Date Issued
2016-02-05
Date Acceptance
2016-02-05
Citation
Trends in Molecular Medicine, 2016, 22 (3), pp.185-187
ISSN
1471-4914
Publisher
Elsevier (Cell Press)
Start Page
185
End Page
187
Journal / Book Title
Trends in Molecular Medicine
Volume
22
Issue
3
Copyright Statement
© 2016, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor
Wellcome Trust
Identifier
PII: S1471-4914(16)00029-0
Grant Number
099276/Z/12/Z
Subjects
Immunology
06 Biological Sciences
11 Medical And Health Sciences
Publication Status
Published