Type 1 diabetes mellitus disease burden in high health expenditure countries between 1990 and 2019
Author(s)
Type
Journal Article
Abstract
Objective:
This observational study assesses trends in type 1 diabetes mellitus (T1DM) disease burden across the 19 countries of the European Union (EU) 15+ between 1990 and 2019.
Methods:
The Global Burden of Disease Study database was used to gather T1DM age-standardised incidence (ASIR), prevalence (ASPR), mortality (ASMR), and disability-adjusted life-year (DALY) rates per 100,000 for each EU15+ country (1990 – 2019). Joinpoint regression analysis was used to describe the trends.
Results:
From 1990 to 2019, T1DM ASIRs and ASPRs increased globally except for females in Finland (−2.9% and −9.4%), the largest increase in ASPR for males and females was observed in France (+144.4% and +137.5% respectively). All had reductions in ASMRs for males and females, with the largest observed in Spain (−56.7% and −79.0% respectively). Trends in DALYs were variable across countries, with increases in DALYs noted in 14/19 for males, and 9/19 for females. Denmark, Finland, Norway, Netherlands, and Sweden had a reduction in DALYs for both males and females.
Conclusions:
Mortality from T1DM is reducing across EU15+ countries, despite concomitant increases in incidence and prevalence rates. Trends in DALYs are variable across countries, reflecting differential trends in the disease burden across countries with similarly high health expenditure.
This observational study assesses trends in type 1 diabetes mellitus (T1DM) disease burden across the 19 countries of the European Union (EU) 15+ between 1990 and 2019.
Methods:
The Global Burden of Disease Study database was used to gather T1DM age-standardised incidence (ASIR), prevalence (ASPR), mortality (ASMR), and disability-adjusted life-year (DALY) rates per 100,000 for each EU15+ country (1990 – 2019). Joinpoint regression analysis was used to describe the trends.
Results:
From 1990 to 2019, T1DM ASIRs and ASPRs increased globally except for females in Finland (−2.9% and −9.4%), the largest increase in ASPR for males and females was observed in France (+144.4% and +137.5% respectively). All had reductions in ASMRs for males and females, with the largest observed in Spain (−56.7% and −79.0% respectively). Trends in DALYs were variable across countries, with increases in DALYs noted in 14/19 for males, and 9/19 for females. Denmark, Finland, Norway, Netherlands, and Sweden had a reduction in DALYs for both males and females.
Conclusions:
Mortality from T1DM is reducing across EU15+ countries, despite concomitant increases in incidence and prevalence rates. Trends in DALYs are variable across countries, reflecting differential trends in the disease burden across countries with similarly high health expenditure.
Date Issued
2023-11
Date Acceptance
2023-12-05
Citation
Diabetes and Vascular Disease Research, 2023, 20 (6)
ISSN
1479-1641
Publisher
SAGE Publications
Journal / Book Title
Diabetes and Vascular Disease Research
Volume
20
Issue
6
Copyright Statement
© The Author(s) 2023. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
License URL
Identifier
https://journals.sagepub.com/doi/10.1177/14791641231221763
Publication Status
Published
Date Publish Online
2023-12-21