A combined X-ray scattering and simulation study of halothane in membranes at raised pressures
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Published version
Author(s)
Type
Journal Article
Abstract
Using a combination of high pressure wide angle X-ray scattering exper-
iments and molecular dynamics simulations, we probe the e ect of the
archetypal general anaesthetic halothane on the lipid hydrocarbon chain
packing and ordering in model bilayers and the variation in these parame-
ters with pressure. Incorporation of halothane into the membrane causes an
expansion of the lipid hydrocarbon chain packing at all pressures but the
e ect of halothane incorporation on the hydrocarbon chain order parameter
is signi cantly reduced at elevated pressure.
iments and molecular dynamics simulations, we probe the e ect of the
archetypal general anaesthetic halothane on the lipid hydrocarbon chain
packing and ordering in model bilayers and the variation in these parame-
ters with pressure. Incorporation of halothane into the membrane causes an
expansion of the lipid hydrocarbon chain packing at all pressures but the
e ect of halothane incorporation on the hydrocarbon chain order parameter
is signi cantly reduced at elevated pressure.
Date Issued
2017-01-04
Date Acceptance
2016-12-16
Citation
Chemical Physics Letters, 2017, 671, pp.21-27
ISSN
0009-2614
Publisher
Elsevier
Start Page
21
End Page
27
Journal / Book Title
Chemical Physics Letters
Volume
671
Copyright Statement
© 2017 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://
creativecommons.org/licenses/by/4.0/).
creativecommons.org/licenses/by/4.0/).
License URL
Sponsor
Engineering & Physical Science Research Council (EPSRC)
Identifier
http://www.sciencedirect.com/science/article/pii/S000926141630999X
Grant Number
EP/J017566/1
Subjects
Chemical Physics
02 Physical Sciences
03 Chemical Sciences
10 Technology
Publication Status
Published