Common variants associated with plasma triglycerides and risk for coronary artery disease
Author(s)
Type
Journal Article
Abstract
Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in epidemiological studies, increased triglyceride levels correlate with higher risk for coronary artery disease (CAD). However, it is unclear whether this association reflects causal processes. We used 185 common variants recently mapped for plasma lipids (P < 5 × 10−8 for each) to examine the role of triglycerides in risk for CAD. First, we highlight loci associated with both low-density lipoprotein cholesterol (LDL-C) and triglyceride levels, and we show that the direction and magnitude of the associations with both traits are factors in determining CAD risk. Second, we consider loci with only a strong association with triglycerides and show that these loci are also associated with CAD. Finally, in a model accounting for effects on LDL-C and/or high-density lipoprotein cholesterol (HDL-C) levels, the strength of a polymorphism's effect on triglyceride levels is correlated with the magnitude of its effect on CAD risk. These results suggest that triglyceride-rich lipoproteins causally influence risk for CAD.
Date Issued
2013-11-01
Date Acceptance
2013-09-13
Citation
Nature Genetics, 2013, 45 (11), pp.1345-1352
ISSN
1061-4036
Publisher
Nature Research
Start Page
1345
End Page
1352
Journal / Book Title
Nature Genetics
Volume
45
Issue
11
Copyright Statement
© 2013 Springer-Nature. The final publication is available at Springer via https://doi.org/10.1038/ng.2795
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000326384100015&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Genetics & Heredity
HIGH-DENSITY-LIPOPROTEIN
MENDELIAN RANDOMIZATION
HEART-DISEASE
CARDIOVASCULAR-DISEASE
GENETIC EPIDEMIOLOGY
CHOLESTEROL LEVELS
LOCI
CONTRIBUTE
THERAPY
Publication Status
Published
Date Publish Online
2013-10-06