Septins and bacterial infection
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Author(s)
Torraca, V
Mostowy, S
Type
Journal Article
Abstract
Septins, a unique cytoskeletal component associated with cellular
membranes, are increasingly recognized as having important roles in host defense against bacterial infection. A role for septins during
invasion of Listeria monocytogenes into host cells was first proposed in 2002. Since then, work has shown that septins assemble in response to a wide variety of invasive bacterial pathogens, and septin assemblies can have different roles during
the bacterial infection process. Here we review the interplay between septins and bacterial pathogens, highlighting septin
s as a structural determinant of host defense. We also discuss
how investigation of septin assembly in response to bacterial infection can yield insight into basic cellular processes including phagocytosis, autophagy, and mitochondrial dynamics.
membranes, are increasingly recognized as having important roles in host defense against bacterial infection. A role for septins during
invasion of Listeria monocytogenes into host cells was first proposed in 2002. Since then, work has shown that septins assemble in response to a wide variety of invasive bacterial pathogens, and septin assemblies can have different roles during
the bacterial infection process. Here we review the interplay between septins and bacterial pathogens, highlighting septin
s as a structural determinant of host defense. We also discuss
how investigation of septin assembly in response to bacterial infection can yield insight into basic cellular processes including phagocytosis, autophagy, and mitochondrial dynamics.
Date Issued
2016-11-11
Date Acceptance
2016-10-26
Citation
Frontiers in Cell and Developmental Biology, 2016, 4
ISSN
2296-634X
Publisher
Frontiers Media
Journal / Book Title
Frontiers in Cell and Developmental Biology
Volume
4
Copyright Statement
© 2016 Torraca and Mostowy. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Sponsor
Wellcome Trust
Lister Institute of Preventive Medicine
Commission of the European Communities
Grant Number
097411/Z/11/ZR
n/a
700088
Subjects
Listeria
Shigella
actin
autophagy
cell-autonomous immunity
cytoskeleton
mitochondria
septins
Publication Status
Published
Article Number
127
Date Publish Online
2016-11-11