Dear Spiral user, We’re pleased to introduce Helix, https://helix.imperial.ac.uk/ Imperial’s new repository for research datasets. Please use Helix for all future dataset deposits. There is no change to Spiral - continue depositing as usual. For queries, contact the Research Data Management team at rdm-enquiries@imperial.ac.uk. Kind regards, the Spiral Team. The Spiral team
High HTLV-1 proviral load predates and predicts HTLV-1-associated disease: literature review and the London experience
File(s)
pathogens-13-00553.pdf (754.52 KB)
Published version
Author(s)
Taylor, Graham P
Evans, William
Rosadas, Carolina
Type
Journal Article
Abstract
Human T cell lymphotropic virus type 1 (HTLV-1) is a retrovirus that infects lymphocytes and causes severe diseases. HTLV-1 proviral load (PVL), i.e., the number of host cells that carry HTLV-1 proviral DNA integrated into their genome, can be measured in peripheral blood mononuclear cells (PBMCs) using quantitative polymerase chain reaction. In this narrative review, we discuss the usefulness of HTLV-1 PVL quantification and share our experience acquired during more than 30 years of follow-up of people living with HTLV-1 in the UK. Patients with HTLV-1-associated myelopathy have higher PVL than those with asymptomatic infection. This is consistent across studies in different countries. High PVL predates symptom onset for both inflammatory and proliferative diseases. High PVL is essential but not sufficient for the development of HTLV-1-associated diseases. Therefore, PVL quantification can be used to support the care of people living with HTLV-1 by identifying those most at risk of HTLV-1-associated diseases.
Date Issued
2024-07
Date Acceptance
2024-06-19
Citation
Pathogens, 2024, 13 (7)
URI
URL
DOI
ISSN
2076-0817
Publisher
MDPI
Journal / Book Title
Pathogens
Volume
13
Issue
7
Copyright Statement
© 2024 by the authors.
Licensee MDPI, Basel, Switzerland.
This article is an open access article
distributed under the terms and
conditions of the Creative Commons
Attribution (CC BY) license (https://
creativecommons.org/licenses/by/
4.0/).
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/39057780
Subjects
diseases
HAM
HTLV-1
outcome
PCR
prognostic marker
proviral load
Publication Status
Published
Coverage Spatial
Switzerland
Article Number
553
Date Publish Online
2024-07-01