Seven challenges in modeling pathogen dynamics within-host and across scales
Author(s)
Type
Journal Article
Abstract
The population dynamics of infectious disease is a mature field in terms of theory and to some extent, application. However for microparasites, the theory and application of models of the dynamics within a single infected host is still an open field. Further, connecting across the scales – from cellular to host level, to population level – has potential to vastly improve our understanding of pathogen dynamics and evolution. Here, we highlight seven challenges in the following areas: transmission bottlenecks, heterogeneity within host, dynamic fitness landscapes within hosts, making use of next-generation sequencing data, capturing superinfection and when and how to model more than two scales.
Date Issued
2014-09-30
Date Acceptance
2014-09-21
Citation
Epidemics, 2014, 10, pp.45-48
ISSN
1878-0067
Publisher
Elsevier
Start Page
45
End Page
48
Journal / Book Title
Epidemics
Volume
10
Copyright Statement
© 2014 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND
license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
License URL
Subjects
Science & Technology
Life Sciences & Biomedicine
Infectious Diseases
Within-host
Multiple scales
Superinfection
Transmission bottlenecks
Deep-sequencing
INFLUENZA-VIRUS
EVOLUTIONARY DYNAMICS
HIV-1 INFECTION
IMMUNITY
TRANSMISSION
ADAPTATION
MECHANISMS
REGION
Publication Status
Published