Variable outcomes of human heart attack recapitulated in genetically diverse mice
File(s)
Author(s)
Type
Journal Article
Abstract
Clinical variation in patient responses to myocardial infarction (MI) has been difficult to model in laboratory animals. To assess the genetic basis of variation in outcomes after heart attack, we characterized responses to acute MI in the Collaborative Cross (CC), a multi-parental panel of genetically diverse mouse strains. Striking differences in post-MI functional, morphological, and myocardial scar features were detected across 32 CC founder and recombinant inbred strains. Transcriptomic analyses revealed a plausible link between increased intrinsic cardiac oxidative phosphorylation levels and MI-induced heart failure. The emergence of significant quantitative trait loci for several post-MI traits indicates that utilizing CC strains is a valid approach for gene network discovery in cardiovascular disease, enabling more accurate clinical risk assessment and prediction.
Date Issued
2019-03-04
Date Acceptance
2019-01-10
Citation
npj Regenerative Medicine, 2019, 4, pp.1-15
ISSN
2057-3995
Publisher
Nature Research (part of Springer Nature)
Start Page
1
End Page
15
Journal / Book Title
npj Regenerative Medicine
Volume
4
Copyright Statement
© The Author(s) 2019. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000467912300001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Technology
Cell & Tissue Engineering
Engineering, Biomedical
Cell Biology
Engineering
COLLABORATIVE CROSS
MYOCARDIAL-INFARCTION
RAPID IDENTIFICATION
MOUSE MODEL
FAILURE
RESOURCE
SUSCEPTIBILITY
REGULATOR
MYOPATHY
DISEASES
Publication Status
Published
Article Number
UNSP 5
Date Publish Online
2019-03-04