Applications of synthetic yeast consortia for the production of native and non-native chemicals
File(s)
Accepted version
Author(s)
Darvishi, Farshad
Rafatiyan, Sajad
Abbaspour Motlagh Moghaddam, Mohammad Hossein
Atkinson, Eliza
Ledesma-Amaro, Rodrigo
Type
Journal Article
Abstract
The application of microbial consortia is a new approach in synthetic biology. Synthetic yeast consortia, simple or complex synthetic mixed cultures, have been used for the production of various metabolites. Cooperation between the members of a consortium and cross-feeding can be applied to create stable microbial communication. These consortia can: consume a variety of substrates, perform more complex functions, produce metabolites in high titer, rate, and yield (TRY), and show higher stability during industrial fermentations. Due to the new research context of synthetic consortia, few yeasts were used to build these consortia, including Saccharomyces cerevisiae, Pichia pastoris, and Yarrowia lipolytica. Here, application of the yeasts for design of synthetic microbial consortia and their advantages and bottlenecks for effective and robust production of valuable metabolites from bioresource, including: cellulose, xylose, glycerol and so on, have been reviewed. Key trends and challenges are also discussed for the future development of synthetic yeast consortia.
Date Issued
2024-01-01
Date Acceptance
2022-08-19
Citation
Critical Reviews in Biotechnology, 2024, 44 (1), pp.15-30
ISSN
0738-8551
Publisher
Taylor and Francis Group
Start Page
15
End Page
30
Journal / Book Title
Critical Reviews in Biotechnology
Volume
44
Issue
1
Copyright Statement
© 2022 Informa UK Limited, trading as Taylor & Francis Group. The final publication is available at Springer via https://doi.org/10.1080/07388551.2022.2118569
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/36130800
Subjects
biochemicals
bioresource
non-native
Synthetic biology
synthetic consortia
yeast
Publication Status
Published
Coverage Spatial
England
Date Publish Online
2022-09-21