Expression of Cancer/Testis genes in ductal carcinoma in situ and benign lesions of the breast.
Author(s)
Type
Journal Article
Abstract
Cancer/testis (CT) genes represent a unique class of genes, which are expressed by germ cells, normally silenced in somatic cells, but activated in various cancers. CT proteins can elicit spontaneous immune responses in cancer patients and this feature makes them attractive targets for immunotherapy-based approaches. We have previously reported that CTs are relatively commonly expressed in estrogen receptor (ER) negative, high risk carcinomas. In this study, we examined the expression of selected CT genes in ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and benign proliferative lesions of the breast. ER negative DCIS were found to be associated with significant CT gene expression together with HER2 positivity and a marked stromal immune response.
Date Issued
2014-01-01
Date Acceptance
2013-12-10
ISSN
2331-4737
Start Page
14
End Page
20
Journal / Book Title
Oncoscience
Volume
1
Issue
1
Copyright Statement
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use,
distribution, and reproduction in any medium, provided the original author and source are credited.
distribution, and reproduction in any medium, provided the original author and source are credited.
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/25593980
Subjects
DCIS
ER negative
cancer/testis genes
Publication Status
Published online
Coverage Spatial
United States