Theory of neuronal perturbome in cortical networks.
File(s)Sadeh.pdf (1.9 MB)
Published version
Author(s)
Sadeh, S
Clopath, C
Type
Journal Article
Abstract
To unravel the functional properties of the brain, we need to untangle how neurons interact with each other and coordinate in large-scale recurrent networks. One way to address this question is to measure the functional influence of individual neurons on each other by perturbing them in vivo. Application of such single-neuron perturbations in mouse visual cortex has recently revealed feature-specific suppression between excitatory neurons, despite the presence of highly specific excitatory connectivity, which was deemed to underlie feature-specific amplification. Here, we studied which connectivity profiles are consistent with these seemingly contradictory observations, by modeling the effect of single-neuron perturbations in large-scale neuronal networks. Our numerical simulations and mathematical analysis revealed that, contrary to the prima facie assumption, neither inhibition dominance nor broad inhibition alone were sufficient to explain the experimental findings; instead, strong and functionally specific excitatory-inhibitory connectivity was necessary, consistent with recent findings in the primary visual cortex of rodents. Such networks had a higher capacity to encode and decode natural images, and this was accompanied by the emergence of response gain nonlinearities at the population level. Our study provides a general computational framework to investigate how single-neuron perturbations are linked to cortical connectivity and sensory coding and paves the road to map the perturbome of neuronal networks in future studies.
Date Issued
2020-10-27
Online Publication Date
2020-11-10T11:25:02Z
Date Acceptance
2020-10-01
ISSN
0027-8424
Publisher
National Academy of Sciences
Start Page
26966
End Page
26976
Journal / Book Title
Proceedings of the National Academy of Sciences of USA
Volume
117
Issue
43
Copyright Statement
© 2020 the Author(s). Published by PNAS. This open access article is distributed under Creative Commons Attribution License 4.0 (CC BY).
License URI
Sponsor
Wellcome Trust
Simons Foundation
Engineering & Physical Science Research Council (EPSRC)
Biotechnology and Biological Sciences Research Cou
Biotechnology and Biological Sciences Research Council (BBSRC)
Identifier
https://www.pnas.org/content/117/43/26966/tab-article-info
https://www.ncbi.nlm.nih.gov/pubmed/33055215
2004568117
Grant Number
200790/Z/16/Z
Award ID:564408
EP/R035806/1
ORCA 64155 (BB/N013956/1)
BB/P018785/1
Subjects
cortical connectivity
neuronal perturbation
perturbome
sensory coding
visual cortex
cortical connectivity
neuronal perturbation
perturbome
sensory coding
visual cortex
Publication Status
Published
Country
United States
Date Publish Online
2020-10-14