The contribution of infection and the respiratory microbiome in acute exacerbations of idiopathic pulmonary fibrosis
File(s)
Published version
Author(s)
Invernizzi, Rachele
Molyneaux, Philip L
Type
Journal Article
Abstract
Idiopathic pulmonary fibrosis (IPF) arises in genetically susceptible individuals as a result of an aberrant wound-healing response following repetitive alveolar injury. The clinical course of the disease remains both variable and unpredictable with periods of more rapid decline, termed acute exacerbation of IPF (AE-IPF), often punctuating the disease trajectory. Exacerbations carry a significant morbidity and mortality, and their exact pathogenesis remains unclear. Given the emerging evidence that disruption and alteration in the lung microbiome plays a role in the pathogenesis and progression of IPF, this review discusses the current knowledge of the contribution of infection and the respiratory microbiome to AE-IPF.
Date Issued
2019-06-30
Date Acceptance
2019-06-16
Citation
European Respiratory Review, 2019, 28 (152)
ISSN
0905-9180
Publisher
European Respiratory Society
Journal / Book Title
European Respiratory Review
Volume
28
Issue
152
Copyright Statement
©ERS 2019. http://creativecommons.org/licenses/by-nc/4.0/This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0 (https://creativecommons.org/licenses/by/4.0/)
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/31285290
PII: 28/152/190045
Subjects
Respiratory System
Publication Status
Published
Coverage Spatial
England
Date Publish Online
2019-07-08