The autonomic nervous system as a therapeutic target in heart failure: a scientific position statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology
File(s)
Author(s)
Type
Journal Article
Abstract
Despite improvements in medical therapy and device-based treatment, heart failure (HF) continues to impose enormous burdens on patients and health care systems worldwide. Alterations in autonomic nervous system (ANS) activity contribute to cardiac disease progression, and the recent development of invasive techniques and electrical stimulation devices has opened new avenues for specific targeting of the sympathetic and parasympathetic branches of the ANS. The Heart Failure Association of the European Society of Cardiology recently organized an expert workshop which brought together clinicians, trialists and basic scientists to discuss the ANS as a therapeutic target in HF. The questions addressed were: (i) What are the abnormalities of ANS in HF patients? (ii) What methods are available to measure autonomic dysfunction? (iii) What therapeutic interventions are available to target the ANS in patients with HF, and what are their specific strengths and weaknesses? (iv) What have we learned from previous ANS trials? (v) How should we proceed in the future?
Date Issued
2017-09-26
Date Acceptance
2017-05-24
Citation
European Journal of Heart Failure, 2017, 19 (11), pp.1361-1378
ISSN
1388-9842
Publisher
Wiley
Start Page
1361
End Page
1378
Journal / Book Title
European Journal of Heart Failure
Volume
19
Issue
11
Copyright Statement
© 2017 The Authors. European Journal of Heart Failure © 2017 European Society of Cardiology. This is the accepted version of the article, which has been published in final form at https://dx.doi.org/10.1002/ejhf.921
Sponsor
British Heart Foundation
British Heart Foundation
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000418670800005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Grant Number
FS/11/67/28954
RM/13/1/30157
Subjects
Science & Technology
Life Sciences & Biomedicine
Cardiac & Cardiovascular Systems
Cardiovascular System & Cardiology
Heart failure
Sympathetic
Parasympathetic
Devices and nerve ablation
Autonomic dysfunction
OBSTRUCTIVE SLEEP-APNEA
BAROREFLEX ACTIVATION THERAPY
REDUCED EJECTION FRACTION
RENAL SYMPATHETIC DENERVATION
CARDIAC RESYNCHRONIZATION THERAPY
RANDOMIZED CONTROLLED-TRIAL
LEFT-VENTRICULAR DYSFUNCTION
ACUTE MYOCARDIAL-INFARCTION
ADAPTIVE SERVO-VENTILATION
RHEOS PIVOTAL TRIAL
Publication Status
Published