Potential hormone mechanisms of bariatric surgery
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Author(s)
Dimitriadis, Georgios K
Randeva, Manpal S
Miras, Alexander D
Type
Journal Article
Abstract
Purpose of Review
In recent years, the role of the gastrointestinal (GI) tract in energy homeostasis through modulation of the digestion and absorption of carbohydrates and the production of incretin hormones is well recognized.
Recent Findings
Bariatric surgery for obesity has been a very effective method in substantially improving weight, and numerous studies have focused on intestinal adaptation after bariatric procedures. A number of structural and functional changes in the GI tract have been reported postsurgery, which could be responsible for the altered hormonal responses. Furthermore, the change in food absorption rate and the intestinal regions exposed to carbohydrates may affect blood glucose response.
Summary
This review hopes to give new insights into the direct role of gut hormones, by summarising the metabolic effects of bariatric surgery.
In recent years, the role of the gastrointestinal (GI) tract in energy homeostasis through modulation of the digestion and absorption of carbohydrates and the production of incretin hormones is well recognized.
Recent Findings
Bariatric surgery for obesity has been a very effective method in substantially improving weight, and numerous studies have focused on intestinal adaptation after bariatric procedures. A number of structural and functional changes in the GI tract have been reported postsurgery, which could be responsible for the altered hormonal responses. Furthermore, the change in food absorption rate and the intestinal regions exposed to carbohydrates may affect blood glucose response.
Summary
This review hopes to give new insights into the direct role of gut hormones, by summarising the metabolic effects of bariatric surgery.
Date Issued
2017-09-01
Date Acceptance
2017-08-01
Citation
Current Obesity Reports, 2017, 6 (3), pp.253-265
ISSN
2162-4968
Publisher
Springer
Start Page
253
End Page
265
Journal / Book Title
Current Obesity Reports
Volume
6
Issue
3
Copyright Statement
© The Author(s) 2017. This article is an open access publication. This article is distributed under the terms of the Creative
Commons Attribution 4.0 International License (http://
creativecommons.org/licenses/by/4.0/), which permits unrestricted use,
distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the
Creative Commons license, and indicate if changes were made.
Commons Attribution 4.0 International License (http://
creativecommons.org/licenses/by/4.0/), which permits unrestricted use,
distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the
Creative Commons license, and indicate if changes were made.
License URL
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000408452800004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Endocrinology & Metabolism
Nutrition & Dietetics
Bariatric surgery
Gastric banding
Sleeve gastrectomy
Roux-en-Y gastric bypass
Gut hormones
Gastrin
GLP-1
GLP-2
PYY
Ghrelin
CCK
GIP
Oxyntomodulin
Secretin
VIP
PP
Insulin
Glucagon
Somatostatin
Obestatin
Gustducin
FGF19
FGF21
Y GASTRIC BYPASS
GLUCAGON-LIKE PEPTIDE-1
INDUCED WEIGHT-LOSS
BETA-CELL FUNCTION
LAPAROSCOPIC SLEEVE GASTRECTOMY
DUODENAL-JEJUNAL EXCLUSION
TYPE-2 DIABETIC SUBJECTS
GOTO-KAKIZAKI RATS
FOOD-INTAKE
GUT HORMONES
Publication Status
Published
Date Publish Online
2017-08-05