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Resection of the large bowel suppresses hunger and food intake and modulates gastrointestinal fermentation.
File(s)
Author(s)
Hettiarachchi, P
Wickremasinghe, AR
Frost, GS
Deen, KI
Pathirana, AA
Type
Journal Article
Abstract
OBJECTIVE: To assess appetite and gut hormone levels in patients following partial (PR) or total resection (TR) of the large bowel. METHODS: A comparative cross sectional study was carried out with healthy controls (n = 99) and patients who had undergone PR (n = 64) or TR (n = 12) of the large bowel. Participants consumed a standard (720 kcal) breakfast meal at 0830 (t = 0) h followed by lactulose (15 g) and a buffet lunch (t = 210 min). Participants rated the subjective feelings of hunger at t = -30, 0, 30, 60, 120, and 180 min. Breath hydrogen (BH) concentrations were also evaluated. In a matched subset (11 controls, 11 PR and 9 TR patients) PYY and GLP-1 concentrations were measured following breakfast. The primary outcome measure was appetite, as measured using visual analogue scales and the buffet lunch. The secondary outcome was BH concentrations following a test meal. RESULTS: PR and TR participants had lower hunger and energy intake at the buffet lunch meal compared to controls. PR subjects had higher BH concentrations compared to controls and TR subjects. BH levels correlated with circulating GLP-1 levels at specific time points. CONCLUSIONS: PR or TR of the large bowel reduced feelings of hunger and energy intake, and PR increased gastrointestinal fermentation.
Date Issued
2016-07-27
Date Acceptance
2016-04-19
Citation
Obesity, 2016, 24 (8), pp.1723-1730
URI
DOI
ISSN
1930-7381
Publisher
Wiley
Start Page
1723
End Page
1730
Journal / Book Title
Obesity
Volume
24
Issue
8
Copyright Statement
This is the peer reviewed version of the following article: Hettiarachchi, P., Wickremasinghe, A. R., Frost, G. S., Deen, K. I., Pathirana, A. A., Murphy, K. G. and Jayaratne, S. D. (2016), Resection of the large bowel suppresses hunger and food intake and modulates gastrointestinal fermentation. Obesity, 24: 1723–1730, which has been published in final form at https://dx.doi.org/10.1002/oby.21550.  This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.
Subjects
Endocrinology & Metabolism
MD Multidisciplinary
Publication Status
Published