Development of neonatal brain functional centrality and alterations associated with preterm birth
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
Formation of the functional connectome in early life underpins future learning and behavior. However, our understanding of how the functional organization of brain regions into interconnected hubs (centrality) matures in the early postnatal period is limited, especially in response to factors associated with adverse neurodevelopmental outcomes such as preterm birth. We characterized voxel-wise functional centrality (weighted degree) in 366 neonates from the Developing Human Connectome Project. We tested the hypothesis that functional centrality matures with age at scan in term-born babies and is disrupted by preterm birth. Finally, we asked whether neonatal functional centrality predicts general neurodevelopmental outcomes at 18 months. We report an age-related increase in functional centrality predominantly within visual regions and a decrease within the motor and auditory regions in term-born infants. Preterm-born infants scanned at term equivalent age had higher functional centrality predominantly within visual regions and lower measures in motor regions. Functional centrality was not related to outcome at 18 months old. Thus, preterm birth appears to affect functional centrality in regions undergoing substantial development during the perinatal period. Our work raises the question of whether these alterations are adaptive or disruptive and whether they predict neurodevelopmental characteristics that are more subtle or emerge later in life.
Date Issued
2023-05-01
Date Acceptance
2022-10-11
Citation
Cerebral Cortex, 2023, 33 (9), pp.5585-5596
ISSN
1047-3211
Publisher
Oxford University Press
Start Page
5585
End Page
5596
Journal / Book Title
Cerebral Cortex
Volume
33
Issue
9
Copyright Statement
© The Author(s) 2022. Published by Oxford University Press.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
License URL
Identifier
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000893181500001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
Subjects
AGE
ARCHITECTURE
ARTIFACT
AUTISM
BORN
brain development
CONNECTIVITY
functional centrality
HUBS
IMPACT
Life Sciences & Biomedicine
neonatal
NETWORKS
Neurosciences
Neurosciences & Neurology
preterm birth
REGRESSION
resting-state connectivity
Science & Technology
Publication Status
Published
Date Publish Online
2022-11-20