A systematic review of paediatric deep venous thrombolysis
File(s)
Author(s)
Taha, H
Busuttil, Andrew
Bootun, Roshan
Davies, Alun H
Type
Journal Article
Abstract
Objectives:
The aim was to assess the effectiveness and safety of Catheter Directed Thrombolysis (CDT) in children with deep venous thrombosis (DVTs) and to evaluate its long-term effect.
Method and Results:
EMBASE, Medline and Cochrane databases were searched to identify studies in which paediatric acute DVT patients received thrombolysis. Following title and abstract screening, 7cohort studies with total of 183 patients were identified. Technical success was 82%, and superior in regional rather than systemic thrombolysis (p< .00001). One cohort study identified significant difference in thrombus resolution at 1 year between thrombolytic and anticoagulant groups (p=0.01). The complication rate was low, with incidence rates of major bleeding, pulmonary embolism (PE) and others at 2.8%, 1.8% and 8.4%, respectively. The overall PTS rate was 12.7%. The incidence of re-thrombosis ranged from 12.3%-27%.
Conclusion:
Thrombolysis for paediatric DVT is an effective and relatively safe therapeutic option, lowering the incidence of PTS and DVT recurrence.
The aim was to assess the effectiveness and safety of Catheter Directed Thrombolysis (CDT) in children with deep venous thrombosis (DVTs) and to evaluate its long-term effect.
Method and Results:
EMBASE, Medline and Cochrane databases were searched to identify studies in which paediatric acute DVT patients received thrombolysis. Following title and abstract screening, 7cohort studies with total of 183 patients were identified. Technical success was 82%, and superior in regional rather than systemic thrombolysis (p< .00001). One cohort study identified significant difference in thrombus resolution at 1 year between thrombolytic and anticoagulant groups (p=0.01). The complication rate was low, with incidence rates of major bleeding, pulmonary embolism (PE) and others at 2.8%, 1.8% and 8.4%, respectively. The overall PTS rate was 12.7%. The incidence of re-thrombosis ranged from 12.3%-27%.
Conclusion:
Thrombolysis for paediatric DVT is an effective and relatively safe therapeutic option, lowering the incidence of PTS and DVT recurrence.
Date Issued
2019-04-01
Date Acceptance
2018-04-19
Citation
journals.sagepub.com/home/phl
ISSN
0268-3555
Publisher
SAGE Publications
Start Page
179
End Page
190
Journal / Book Title
journals.sagepub.com/home/phl
Volume
34
Issue
3
Copyright Statement
©The Author(s) 2018. The final, definitive version of this paper has been published by Sage Publications Ltd. All rights reserved. It is available at: https://journals.sagepub.com/doi/10.1177/0268355518778660
Subjects
Science & Technology
Life Sciences & Biomedicine
Surgery
Peripheral Vascular Disease
Cardiovascular System & Cardiology
Thrombolysis
children
paediatric
deep venous thrombosis
post-thrombotic syndrome
systematic review
TISSUE-PLASMINOGEN-ACTIVATOR
VEIN THROMBOSIS
POSTTHROMBOTIC SYNDROME
ANTITHROMBOTIC THERAPY
RT-PA
CHILDREN
PREVENTION
MANAGEMENT
TRIAL
Thrombolysis
children
deep venous thrombosis
paediatric
post-thrombotic syndrome
systematic review
Anticoagulants
Child
Female
Humans
Male
Thrombolytic Therapy
Venous Thrombosis
Cardiovascular System & Hematology
1102 Cardiorespiratory Medicine and Haematology
Publication Status
Published
Date Publish Online
2018-06-03