A framework for Controlled Human Infection Model (CHIM) studies in Malawi: Report of a Wellcome Trust workshop on CHIM in Low Income Countries held in Blantyre, Malawi.
Author(s)
Type
Journal Article
Abstract
Controlled human infection model (CHIM) studies have pivotal importance in vaccine development, being useful for proof of concept, pathogenesis, down-selection and immunogenicity studies. To date, however, they have seldom been carried out in low and middle income countries (LMIC), which is where the greatest burden of vaccine preventable illness is found. This workshop discussed the benefits and barriers to CHIM studies in Malawi. Benefits include improved vaccine effectiveness and host country capacity development in clinical, laboratory and governance domains. Barriers include acceptability, safety and regulatory issues. The report suggests a framework by which ethical, laboratory, scientific and governance issues may be addressed by investigators considering or planning CHIM in LMIC.
Date Issued
2017-08-24
Online Publication Date
2020-08-20T08:51:00Z
Date Acceptance
2017-08-21
ISSN
2398-502X
Publisher
F1000Research
Start Page
70
End Page
70
Journal / Book Title
Wellcome Open Research
Volume
2
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/29018841
Subjects
CHIM
Controlled human infection model
vaccine
workshop report
Wellcome Trust CHIM workshop participants
CHIM
Controlled human infection model
vaccine
workshop report
Publication Status
Published online
Country
England