Laboratory diagnosis of human T-lymphotropic virus in Brazil: assays, flowcharts, challenges, and perspectives
Author(s)
Caterino-de-Araujo, Adele
Barbosa-Stancioli, Edel Figueiredo
Alonso Neto, Jose Boullosa
Aragon, Mayra Goncalves
Galvao-Castro, Bernardo
Type
Journal Article
Abstract
INTRODUCTION
We present a data analysis and review of recent studies regarding the laboratory diagnosis of human T-lymphotropic virus 1 and 2 (HTLV-1/2) infections in Brazil.
METHODS
Target populations, available diagnostic serological assays (screening and complementary tests), molecular assays (in-house), causes of false-positive and false-negative results, and flowcharts were analyzed.
RESULTS
A table presents the target populations, two diagnostic flowcharts (depending on laboratory infrastructure and study population), and recent research that may improve how HTLV-1/2 is diagnosed in Brazil.
CONCLUSIONS:
Our results support the implementation of public policies to reduce HTLV-1/2 transmission and its associated diseases.
We present a data analysis and review of recent studies regarding the laboratory diagnosis of human T-lymphotropic virus 1 and 2 (HTLV-1/2) infections in Brazil.
METHODS
Target populations, available diagnostic serological assays (screening and complementary tests), molecular assays (in-house), causes of false-positive and false-negative results, and flowcharts were analyzed.
RESULTS
A table presents the target populations, two diagnostic flowcharts (depending on laboratory infrastructure and study population), and recent research that may improve how HTLV-1/2 is diagnosed in Brazil.
CONCLUSIONS:
Our results support the implementation of public policies to reduce HTLV-1/2 transmission and its associated diseases.
Date Issued
2021
Date Acceptance
2021-04-26
Citation
Revista da Sociedade Brasileira de Medicina Tropical, 2021, 54
ISSN
0037-8682
Publisher
Sociedade Brasileira de Medicina Tropical (SBMT)
Journal / Book Title
Revista da Sociedade Brasileira de Medicina Tropical
Volume
54
Copyright Statement
This is an open-access article distributed under the terms of the Creative Commons Attribution License
License URL
Identifier
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000672556800001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
Subjects
Algorithms
CARRIERS
Confirmatory assays
Diagnosis
HTLV-1 PROVIRAL LOAD
Human T-lymphotropic virus 1
Human T-lymphotropic virus 2
INDIVIDUALS
Life Sciences & Biomedicine
Parasitology
PERIPHERAL-BLOOD
REAL-TIME PCR
Science & Technology
Screening assays
Tropical Medicine
Publication Status
Published
Article Number
e0175-2021
Date Publish Online
2021-06-02