Assessment of the burden of disease for patients with peripheral artery disease undergoing revascularization in England
Author(s)
Type
Journal Article
Abstract
Background: Symptoms, severity, and acuteness of peripheral artery disease (PAD) are major determinants of severe limb symptoms, subsequent risk of cardiovascular events and mortality. Lower extremity revascularization (LER) is a key option to relieve symptoms and to prevent limb loss in symptomatic PAD patients. This study aimed to quantify the burden of disease among patients with PAD-LER in England. Methods: Retrospective population-based study of linked primary and secondary care electronic health records, included 13,869 adult patients (aged ≥18 years) with PAD-LER from 2003 to 2018. The incidence of first ever PAD-LER was estimated overall and by type of procedure (endovascular/surgical). Health resource utilization associated with PAD-related complications and treatment patterns were assessed. Results: A high annual incidence of lower-limb revascularization (41.2 per 1,000 person years) and a nearly double incidence of endovascular first revascularization compared with open surgery were observed. More than 70% of patients with PAD-LER had a history of hyperlipidaemia and hypertension and roughly one-third were diabetic and had a history of coronary artery disease. Cardiovascular mortality accounting for one-third (34.1 per 1,000 person years) of all-cause mortality. Over 93% of patients were hospitalized for any reason and the commonest reasons for hospitalization were cardiovascular diseases and PAD with about one third hospitalized for revascularization re-occurrence. Conclusion: There is a significant burden of PAD-LER to the individual and society with ongoing healthcare resource utilization, treatment and increasing mortality.
Date Issued
2022-06-07
Date Acceptance
2022-03-30
Citation
Vascular Medicine: the international journal of research review and clinical practice, 2022, 27 (5), pp.440-449
ISSN
1358-863X
Publisher
SAGE Publications
Start Page
440
End Page
449
Journal / Book Title
Vascular Medicine: the international journal of research review and clinical practice
Volume
27
Issue
5
Copyright Statement
© The Author(s) 2022, Article Reuse Guidelines. This work is published under a CC BY licence.
License URL
Identifier
https://journals.sagepub.com/doi/10.1177/1358863X221096704
Publication Status
Published
Date Publish Online
2022-06-07