Novel antimicrobial strategies to treat multi‐drug resistant Staphylococcus aureus infections
Author(s)
Douglas, Edward JA
Wulandari, Sri W
Lovell, Scott D
Laabei, Maisem
Type
Journal Article
Abstract
Antimicrobial resistance is a major obstacle for the treatment of infectious diseases and currently represents one of the most significant threats to global health. Staphylococcus aureus remains a formidable human pathogen with high mortality rates associated with severe systemic infections. S. aureus has become notorious as a multidrug resistant bacterium, which when combined with its extensive arsenal of virulence factors that exacerbate disease, culminates in an incredibly challenging pathogen to treat clinically. Compounding this major health issue is the lack of antibiotic discovery and development, with only two new classes of antibiotics approved for clinical use in the last 20 years. Combined efforts from the scientific community have reacted to the threat of dwindling treatment options to combat S. aureus disease in several innovative and exciting developments. This review describes current and future antimicrobial strategies aimed at treating staphylococcal colonization and/or disease, examining therapies that show significant promise at the preclinical development stage to approaches that are currently being investigated in clinical trials.
Date Issued
2023-07-01
Date Acceptance
2023-04-18
Citation
Microbial Biotechnology, 2023, 16 (7), pp.1456-1474
ISSN
1751-7907
Publisher
Wiley
Start Page
1456
End Page
1474
Journal / Book Title
Microbial Biotechnology
Volume
16
Issue
7
Copyright Statement
© 2023 The Authors. Microbial Biotechnology published by Applied Microbiology International and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
License URL
Publication Status
Published
Date Publish Online
2023-05-13