Heavy chain deposition disease in monoclonal gammopathy of renal significance: a prodrome of multiple myeloma case and literature review
Author(s)
Gnanasampanthan, Sahana
Samelis, Vasileios P
Roufosse, Candice
Kousios, Andreas
Type
Journal Article
Abstract
Monoclonal immunoglobulin deposition disease (MIDD) is a complication of plasma cell dyscrasias, resulting in abnormal immunoglobulin deposition along basement membranes. We describe a case of a 60-year-old male with a complex hospital admission, presenting with critical illness accompanied by acute kidney injury, nephrotic syndrome and moderately elevated serum free light chain (SFLC) ratio, on a background of well-controlled diabetes, hypertension and chronic kidney disease. There was no clear aetiology for his presentation following preliminary examination and investigations, which led to a biopsy diagnosis of heavy chain deposition disease (HCDD) in the context of monoclonal gammopathy of renal significance (MGRS). We explore the importance of understanding the disease course to allow timely biopsy diagnosis and treatment initiation. Our patient required very close follow-up and a wide multi-disciplinary approach, including haematologists, nephrologists and histopathologists, to guide management in a disease for which therapeutic strategies are poorly defined due to limited clinical trial data.
Date Issued
2025-06-10
Date Acceptance
2025-06-08
Citation
Cureus, 2025, 17 (6)
ISSN
2168-8184
Publisher
Springer Science and Business Media LLC
Start Page
e85740
Journal / Book Title
Cureus
Volume
17
Issue
6
Copyright Statement
© Copyright 2025 Gnanasampanthan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/40656361
Subjects
diagnosis of multiple myeloma
heavy proteinuria
kidney disease
monoclonal gammopathy of renal significance
monoclonal immunoglobulin deposition disease
Publication Status
Published
Coverage Spatial
United States
Date Publish Online
2025-06-10