Cheiroarthropathy and tendinopathy in diabetes
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Accepted version
Author(s)
Hill, NE
Roscoe, D
Stacey, MJ
Chew, S
Type
Journal Article
Abstract
Joint problems commonly occur in people with diabetes. Cheiroarthropathy affects the hands and results in painless limited finger joint extension, appearing to be associated with longer diabetes duration and the presence of microvascular complications. The prevalence of cheiroarthropathy seems to be falling, perhaps as a result of improvements in glycaemic management. Non‐enzymatic glycation of collagen results in abnormally crosslinked protein resistant to degradation with subsequent increased build‐up of collagen in joints. The management of cheiroarthropathy is predominantly conservative, with occupational and hand therapy at the forefront. Tendinopathy is more common in people with diabetes than those without, and is associated with obesity and insulin resistance. As with cheiroarthropathy, the exact causative mechanism of tendinopathy in diabetes is not known, but may be linked to inflammation, apoptosis and increased vascularity of affected tendons, driven by hyperinsulinaemia. Local fat pads have also been suggested to play a role in the pathogenesis of tendinopathy.
Date Issued
2019-04-26
Date Acceptance
2019-03-25
Citation
Diabetic Medicine, 2019, 36 (8), pp.939-947
ISSN
0742-3071
Publisher
Wiley
Start Page
939
End Page
947
Journal / Book Title
Diabetic Medicine
Volume
36
Issue
8
Copyright Statement
© 2019 Diabetes UK. This is the accepted version of the following article: Diabet. Med. 36, 939– 947 (2019), which has been published in final form at https://doi.org/10.1111/dme.13955
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000475951400003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Endocrinology & Metabolism
LIMITED JOINT MOBILITY
SKIN COLLAGEN GLYCATION
INFRAPATELLAR FAT PAD
GLYCEMIC CONTROL
ACHILLES TENDINOPATHY
HAND ABNORMALITIES
RISK-FACTORS
MELLITUS
INSULIN
TENDON
Publication Status
Published
Date Publish Online
2019-03-28