Decidual macrophages as therapeutic targets in preterm labour
File(s)
Published version
Author(s)
Paterson, Emilie O
Short, Daniel J
Male, Victoria
Type
Journal Article
Abstract
The initiation of labour in humans remains poorly understood, although there is mounting evidence for a role for decidual macrophages. These may trigger labour by promoting a proinflammatory state, thereby modulating progesterone signalling and weakening fetal membranes. Preclinical work targeting macrophages therapeutically shows promise in preventing preterm labour, underscoring their significance in this process.
Date Issued
2026-01-01
Date Acceptance
2025-06-01
Citation
Trends in Molecular Medicine, 2026, 32 (1), pp.8-10
ISSN
1471-4914
Publisher
Elsevier BV
Start Page
8
End Page
10
Journal / Book Title
Trends in Molecular Medicine
Volume
32
Issue
1
Copyright Statement
© 2025 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons. org/licenses/by/4.0/).
License URL
Publication Status
Published
Date Publish Online
2025-06-16