Virus satellites drive viral evolution and ecology
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Published version
Author(s)
Type
Journal Article
Abstract
Virus satellites are widespread subcellular entities, present both in eukaryotic and in prokaryotic cells. Their modus vivendi involves parasitism of the life cycle of their inducing helper viruses, which assures their transmission to a new host. However, the evolutionary and ecological implications of satellites on helper viruses remain unclear. Here, using staphylococcal pathogenicity islands (SaPIs) as a model of virus satellites, we experimentally show that helper viruses rapidly evolve resistance to their virus satellites, preventing SaPI proliferation, and SaPIs in turn can readily evolve to overcome phage resistance. Genomic analyses of both these experimentally evolved strains as well as naturally occurring bacteriophages suggest that the SaPIs drive the coexistence of multiple alleles of the phage-coded SaPI inducing genes, as well as sometimes selecting for the absence of the SaPI depressing genes. We report similar (accidental) evolution of resistance to SaPIs in laboratory phages used for Staphylococcus aureus typing and also obtain the same qualitative results in both experimental evolution and phylogenetic studies of Enterococcus faecalis phages and their satellites viruses. In summary, our results suggest that helper and satellite viruses undergo rapid coevolution, which is likely to play a key role in the evolution and ecology of the viruses as well as their prokaryotic hosts.
Date Issued
2015-10-01
Date Acceptance
2015-09-25
ISSN
1553-7390
Publisher
Public Library of Science (PLoS)
Journal / Book Title
PLoS Genetics
Volume
11
Issue
10
Copyright Statement
© 2015 Frígols et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000364401600071&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Genetics & Heredity
GRAM-POSITIVE BACTERIA
PATHOGENICITY ISLAND INTERFERENCE
STAPHYLOCOCCUS-AUREUS
VIRULENCE GENES
HELPER PHAGE
COEVOLUTION
FAMILY
ALIGNMENT
PROTEINS
DUTPASES
Bacteriophages
Biological Evolution
DNA Replication
Genomic Islands
Helper Viruses
Phylogeny
Satellite Viruses
Staphylococcus aureus
Viral Proteins
Staphylococcus aureus
Bacteriophages
Satellite Viruses
Helper Viruses
Viral Proteins
Phylogeny
DNA Replication
Genomic Islands
Biological Evolution
Science & Technology
Life Sciences & Biomedicine
Genetics & Heredity
GRAM-POSITIVE BACTERIA
PATHOGENICITY ISLAND INTERFERENCE
STAPHYLOCOCCUS-AUREUS
VIRULENCE GENES
HELPER PHAGE
COEVOLUTION
FAMILY
ALIGNMENT
PROTEINS
DUTPASES
0604 Genetics
Developmental Biology
Publication Status
Published
Article Number
ARTN e1005609