Structure prediction and engineering of de novo proteins
File(s)
Published version
Author(s)
Qi, Lin
Isalan, Mark
Type
Journal Article
Abstract
De novo proteins represent a challenging frontier at the intersection of evolutionary biology and synthetic biology. Broadly, the term encompasses two distinct categories: naturally evolved de novo proteins, which arise from previously non-coding DNA, and synthetically designed de novo proteins, which are created from scratch through computational and experimental methods. This review provides an overview of the definitions, history, functional significance, and investigation methods for both categories. By examining potential challenges in current de novo protein research, this review highlights the growing convergence between natural evolutionary processes and rational protein engineering, reflecting their importance in biological discovery and human innovations.
Date Issued
2025-01-01
Date Acceptance
2025-09-14
Citation
BBA: Proteins and Proteomics, 2025, 1874 (1)
ISSN
1570-9639
Publisher
Elsevier
Journal / Book Title
BBA: Proteins and Proteomics
Volume
1874
Issue
1
Copyright Statement
© 2025 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
License URL
Publication Status
Published
Article Number
141100
Date Publish Online
2025-09-16