Eosinophils are part of the granulocyte response in tuberculosis and promote host resistance in mice
Author(s)
Type
Journal Article
Abstract
Host resistance to Mycobacterium tuberculosis (Mtb) infection requires the activities of multiple leukocyte subsets, yet the roles of the different innate effector cells during tuberculosis are incompletely understood. Here we uncover an unexpected association between eosinophils and Mtb infection. In humans, eosinophils are decreased in the blood but enriched in resected human tuberculosis lung lesions and autopsy granulomas. An influx of eosinophils is also evident in infected zebrafish, mice, and nonhuman primate granulomas, where they are functionally activated and degranulate. Importantly, using complementary genetic models of eosinophil deficiency, we demonstrate that in mice, eosinophils are required for optimal pulmonary bacterial control and host survival after Mtb infection. Collectively, our findings uncover an unexpected recruitment of eosinophils to the infected lung tissue and a protective role for these cells in the control of Mtb infection in mice.
Date Issued
2021-10-04
Date Acceptance
2021-07-13
Citation
Journal of Experimental Medicine, 2021, 218 (10), pp.1-20
ISSN
0022-1007
Publisher
Rockefeller University Press
Start Page
1
End Page
20
Journal / Book Title
Journal of Experimental Medicine
Volume
218
Issue
10
Replaces
10044/1/97907
Copyright Statement
© 2021 Bohrer et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the
publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0
International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0
International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
Sponsor
Wellcome Trust
Wellcome Trust
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000702879300007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Grant Number
104803/Z/14/Z
WDAI_P83556
Subjects
COINFECTION
DEFENSE
DEFICIENT
HEALTH
IMMUNE-RESPONSE
Immunology
INTERFERON-GAMMA
Life Sciences & Biomedicine
Medicine, Research & Experimental
MYCOBACTERIUM-MARINUM INFECTION
PACKAGE
PATHOGENESIS
Research & Experimental Medicine
RNA-SEQ
Science & Technology
Publication Status
Published
Article Number
ARTN e20210469
Date Publish Online
2021-08-04