Predicting the public health impact of a malaria transmission-blocking vaccine
File(s)Malaria transmission-blocking vaccine.pdf (1.22 MB)
Published version
Author(s)
Type
Journal Article
Abstract
Transmission-blocking vaccines that interrupt malaria transmission from humans to mosquitoes are being tested in early clinical trials. The activity of such a vaccine is commonly evaluated using membrane-feeding assays. Understanding the field efficacy of such a vaccine requires knowledge of how heavily infected wild, naturally blood-fed mosquitoes are, as this indicates how difficult it will be to block transmission. Here we use data on naturally infected mosquitoes collected in Burkina Faso to translate the laboratory-estimated activity into an estimated activity in the field. A transmission dynamics model is then utilised to predict a transmission-blocking vaccine’s public health impact alongside existing interventions. The model suggests that school-aged children are an attractive population to target for vaccination. Benefits of vaccination are distributed across the population, averting the greatest number of cases in younger children. Utilising a transmission-blocking vaccine alongside existing interventions could have a substantial impact against malaria.
Date Issued
2021-03-08
Online Publication Date
2021-04-22T09:48:42Z
Date Acceptance
2021-02-11
ISSN
2041-1723
Publisher
Nature Research
Start Page
1
End Page
12
Journal / Book Title
Nature Communications
Volume
12
Issue
1
Copyright Statement
© The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/.
License URI
Sponsor
PATH-Program for Appropriate Technology in Health
Medical Research Council (MRC)
Identifier
https://www.nature.com/articles/s41467-021-21775-3
Grant Number
GAT.0888-30-01618462-COL
MR/R015600/1
Subjects
Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
PLASMODIUM-FALCIPARUM MALARIA
ANOPHELES-GAMBIAE
MOSQUITOS
INFECTION
ELIMINATION
RESERVOIR
ASSAYS
Adolescent
Adult
Burkina Faso
Child
Child, Preschool
Humans
Infant
Malaria
Malaria Vaccines
Malaria, Falciparum
Middle Aged
Prevalence
Public Health
Vaccination
Young Adult
Humans
Malaria
Malaria, Falciparum
Malaria Vaccines
Vaccination
Prevalence
Public Health
Adolescent
Adult
Middle Aged
Child
Child, Preschool
Infant
Burkina Faso
Young Adult
Publication Status
Published online
Article Number
1494
Date Publish Online
2021-03-08