A systematic review of experimental methods to manipulate secondary hyperalgesia in humans: protocol
Author(s)
Madden, VJ
Bedwell, GJ
Chikezie, PC
Rice, ASC
Kamerman, PR
Type
Journal Article
Abstract
Background Neuropathic pain affects 7–10% of people, but responds poorly to pharmacotherapy, indicating a need for better treatments. Mechanistic research on neuropathic pain frequently uses human surrogate models of the secondary hyperalgesia that is a common feature of neuropathic pain. Experimentally induced secondary hyperalgesia has been manipulated with pharmacological and non-pharmacological methods to clarify the relative contributions of different mechanisms to secondary hyperalgesia. However, this literature has not been systematically synthesised. The aim of this systematic review is to identify, describe, and compare methods that have been used to manipulate experimentally induced secondary hyperalgesia in healthy humans. Methods A systematic search strategy will be supplemented by reference list checks and direct contact with identified laboratories to maximise the identification of data reporting the experimental manipulation of experimentally induced secondary hyperalgesia in healthy humans. Duplicated screening, risk of bias assessment, and data extraction procedures will be used. Authors will be asked to provide data as necessary. Data will be pooled and meta-analyses conducted where possible, with subgrouping according to manipulation method. Manipulation methods will be ranked for potency and risk. Discussion The results of this review will provide a useful reference for researchers interested in using experimental methods to manipulate secondary hyperalgesia in humans and will help to clarify the relative contributions of different mechanisms to secondary hyperalgesia.
Date Issued
2019-08-19
Online Publication Date
2020-04-27T13:35:39Z
Date Acceptance
2019-07-26
ISSN
2046-4053
Publisher
BioMed Central
Start Page
1
End Page
6
Journal / Book Title
Systematic Reviews
Volume
8
Issue
1
Copyright Statement
© The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0
International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and
reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to
the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver
(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and
reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to
the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver
(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Identifier
https://systematicreviewsjournal.biomedcentral.com/articles/10.1186/s13643-019-1120-7
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000485467400002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Medicine, General & Internal
General & Internal Medicine
Hyperalgesia
Systematic review
Healthy volunteers
Quantitative sensory testing
Behaviour control
LONG-TERM POTENTIATION
PERIPHERAL NEUROPATHIC PAIN
CAPSAICIN
STIMULATION
DEPRESSION
QUALITY
WOMEN
Behaviour control
Healthy volunteers
Hyperalgesia
Quantitative sensory testing
Systematic review
Science & Technology
Life Sciences & Biomedicine
Medicine, General & Internal
General & Internal Medicine
Hyperalgesia
Systematic review
Healthy volunteers
Quantitative sensory testing
Behaviour control
LONG-TERM POTENTIATION
PERIPHERAL NEUROPATHIC PAIN
CAPSAICIN
STIMULATION
DEPRESSION
QUALITY
WOMEN
11 Medical and Health Sciences
Publication Status
Published
Article Number
ARTN 208
Date Publish Online
2019-08-19