In an article in this edition of the Journal of Muscle Research and Cell Motility, Geeves, Hitchcock-DiGregori and Gunning present a nomenclature founded on the gene and exon structure of tropomyosin that is both clear and unambiguous. Moreover, the authors have ensured that the new names are linked with their sequences in the NCBI database, thus eliminating the uncertainty of linking a protein isoform with its sequence. This nomenclature system has been planned with the support of all the major labs that work with tropomyosin. We recommend that all researchers take note of this scheme and use it.