Lung microbiome in idiopathic pulmonary fibrosis and other interstitial lung diseases
Author(s)
Type
Journal Article
Abstract
Interstitial lung diseases represent a heterogeneous and wide group of diseases in which factors leading to disease initiation and progression are not fully understood. Recent evidence suggests that the lung microbiome might influence the pathogenesis and progression of interstitial lung diseases. In recent years, the utilization of culture-independent methodologies has allowed the identification of complex and dynamic communities of microbes, in patients with interstitial lung diseases. However, the potential mechanisms by which these changes may drive disease pathogenesis and progression are largely unknown. The aim of this review is to discuss the role of the altered lung microbiome in several interstitial lung diseases. Untangling the host–microbiome interaction in the lung and airway of interstitial lung disease patients is a research priority. Thus, lung dysbiosis is a potentially treatable trait across several interstitial lung diseases, and its proper characterization and treatment might be crucial to change the natural history of these diseases and improve outcomes.
Date Issued
2022-01-17
Date Acceptance
2022-01-12
Citation
International Journal of Molecular Sciences, 2022, 23 (2), pp.1-16
ISSN
1422-0067
Publisher
MDPI AG
Start Page
1
End Page
16
Journal / Book Title
International Journal of Molecular Sciences
Volume
23
Issue
2
Copyright Statement
© 2022 by the authors.
Licensee MDPI, Basel, Switzerland.
This article is an open access article
distributed under the terms and
conditions of the Creative Commons
Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Licensee MDPI, Basel, Switzerland.
This article is an open access article
distributed under the terms and
conditions of the Creative Commons
Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
License URL
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000747435800001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Physical Sciences
Biochemistry & Molecular Biology
Chemistry, Multidisciplinary
Chemistry
microbiome
interstitial lung diseases
treatable traits
ACUTE EXACERBATION
INTESTINAL DYSBIOSIS
RESPIRATORY-TRACT
THERAPY
COTRIMOXAZOLE
HEALTH
AZITHROMYCIN
SARCOIDOSIS
ENVIRONMENT
PROGRESSION
Publication Status
Published
Article Number
ARTN 977
Date Publish Online
2022-01-17