Functional native disulfide bridging enables delivery of a potent, stable and targeted antibody-drug conjugate (ADC)
Author(s)
Type
Journal Article
Abstract
Herein we report the use of next generation maleimides (NGMs) for the construction of a potent antibody–drug conjugate (ADC) via functional disulfide bridging. The linker has excellent stability in blood serum and the ADC, armed with monomethyl auristatin E (MMAE), shows excellent potency and cancer cell selectivity in vitro.
Date Issued
2015-06-01
Date Acceptance
2015-05-25
Citation
Chemical Communications, 2015, 51 (53), pp.10624-10627
ISSN
1359-7345
Publisher
Royal Society of Chemistry
Start Page
10624
End Page
10627
Journal / Book Title
Chemical Communications
Volume
51
Issue
53
Copyright Statement
© The Royal Society of Chemistry 2015. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (https://creativecommons.org/licenses/by/3.0/)
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000356453200007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Physical Sciences
Chemistry, Multidisciplinary
Chemistry
THERAPEUTIC INDEX
BREAST-CANCER
BIOCONJUGATION
TRASTUZUMAB
FRAGMENT
STRATEGY
PROTEIN
Publication Status
Published