Murine thymic NK cells: a case of identity
File(s)Male Brady EJI for RPS.doc (219 KB)
Accepted version
Author(s)
Male, V
Brady, HJM
Type
Journal Article
Abstract
Just over a decade ago, it was established that NK cells in the thymus do not follow precisely the same developmental pathway as conventional NK cells that develop in the bone marrow. Subsequently, it has emerged that NK cells are one branch of a family of innate lymphoid cells (ILCs). ILC1s and thymic NK cells have, however, sufficient similarities such that questions have been raised about how distinctive each cell type is from the other. In this issue of European Journal of Immunology, Gabrielli et al. [Eur. J. Immunol. 2017. 47: 800–805] make a detailed study of the transcription factor requirements of murine thymic NK cells. They provide a valuable insight into the distinctive identity of thymic NK cells with regard to Tbet, Nfil3, Id2, and Ets1. In addition, they clarify the nature of DX5 expression on NK cells and ILC‐like cells in the murine thymus.
Date Issued
2017-05-09
Date Acceptance
2017-04-18
Citation
European Journal of Immunology, 2017, 47 (5), pp.797-799
ISSN
0014-2980
Publisher
Wiley
Start Page
797
End Page
799
Journal / Book Title
European Journal of Immunology
Volume
47
Issue
5
Copyright Statement
© 2017 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim. This is the accepted version of the following article, which has been published in final form at https://onlinelibrary.wiley.com/doi/full/10.1002/eji.201747038
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000401010500004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Immunology
Ets1
Id2
ILC1
Natural Killer cell
Nfil3
Tbet
Thymus
Transcription factor
REGULATORY T-CELLS
TUMOR-INFILTRATING CD8(+)
CHRONIC HEPATITIS-B
MEDIATED ANTITUMOR IMMUNITY
GASTRIC EPITHELIAL-CELLS
CHRONIC VIRAL-INFECTION
PD-1 UP-REGULATION
LIGAND 1 PD-L1
PROGRAMMED DEATH-1
DENDRITIC CELLS
Publication Status
Published
Date Publish Online
2017-05-09