Copy number variations in candidate genes and intergenic regions affect body mass index and abdominal obesity in Mexican children
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
Introduction. Increase in body weight is a gradual process that usually begins in childhood and in adolescence as a result of multiple interactions among environmental and genetic factors. This study aimed to analyze the relationship between copy number variants (CNVs) in five genes and four intergenic regions with obesity in Mexican children. Methods. We studied 1423 children aged 6–12 years. Anthropometric measurements and blood levels of biochemical parameters were obtained. Identification of CNVs was performed by real-time PCR. The effect of CNVs on obesity or body composition was assessed using regression models adjusted for age, gender, and family history of obesity. Results. Gains in copy numbers of LEPR and NEGR1 were associated with decreased body mass index (BMI), waist circumference (WC), and risk of abdominal obesity, whereas gain in ARHGEF4 and CPXCR1 and the intergenic regions 12q15c, 15q21.1a, and 22q11.21d and losses in INS were associated with increased BMI and WC. Conclusion. Our results indicate a possible contribution of CNVs in LEPR, NEGR1, ARHGEF4, and CPXCR1 and the intergenic regions 12q15c, 15q21.1a, and 22q11.21d to the development of obesity, particularly abdominal obesity in Mexican children.
Date Issued
2017-03-27
Date Acceptance
2017-02-06
Citation
BioMed Research International, 2017, 2017
ISSN
2314-6133
Publisher
Hindawi Publishing Corporation
Journal / Book Title
BioMed Research International
Volume
2017
Copyright Statement
© 2017 Diana Lizzete Antúnez-Ortiz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000399202800001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Biotechnology & Applied Microbiology
Medicine, Research & Experimental
Research & Experimental Medicine
TYPE-2 DIABETES-MELLITUS
GENOME-WIDE
CHILDHOOD OBESITY
PROMOTER POLYMORPHISM
KLINEFELTER SYNDROME
DEVELOPMENTAL DELAY
EXTREME OBESITY
ASSOCIATION
CHROMOSOME
ONSET
Publication Status
Published
Article Number
ARTN 2432957