Frailty and comorbidity predict first hospitalisation after heart failure diagnosis in primary care: population-based observational study in England
Author(s)
Type
Journal Article
Abstract
Background: frailty has only recently been recognised as important in patients with heart failure (HF), but little has been done to predict the first hospitalisation after diagnosis in unselected primary care populations. Objectives: to predict the first unplanned HF or all-cause admission after diagnosis, comparing the effects of comorbidity and frailty, the latter measured by the recently validated electronic frailty index (eFI). Design: observational study. Setting: primary care in England. Subjects: all adult patients diagnosed with HF in primary care between 2010 and 2013. Methods: we used electronic health records of patients registered with primary care practices sending records to the Clinical Practice Research Datalink (CPRD) in England with linkage to national hospital admissions and death data. Competing-risk time-to-event analyses identified predictors of first unplanned hospitalisation for HF or for any condition after diagnosis. Results: of 6,360 patients, 9% had an emergency hospitalisation for their HF, and 39% had one for any cause within a year of diagnosis; 578 (9.1%) died within a year without having any emergency admission. The main predictors of HF admission were older age, elevated serum creatinine and not being on a beta-blocker. The main predictors of all-cause admission were age, comorbidity, frailty, prior admission, not being on a beta-blocker, low haematocrit and living alone. Frailty effects were largest in patients aged under 85. Conclusions: this study suggests that frailty has predictive power beyond its comorbidity components. HF patients in the community should be assessed for frailty, which should be reflected in future HF guidelines.
Date Issued
2019-05-01
Date Acceptance
2018-12-07
Citation
Age and Ageing, 2019, 48 (3), pp.347-354
ISSN
1468-2834
Publisher
Oxford University Press (OUP)
Start Page
347
End Page
354
Journal / Book Title
Age and Ageing
Volume
48
Issue
3
Copyright Statement
© 2019 The Author(s). Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. For permissions, please email: journals.permissions@oup.com This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model). This is a pre-copy-editing, author-produced version of an article accepted for publication in Age and Ageing following peer review. The definitive publisher-authenticated version: Alex Bottle, Dani Kim, Benedict Hayhoe, Azeem Majeed, Paul Aylin, Andrew Clegg, Martin R Cowie; Frailty and comorbidity predict first hospitalisation after heart failure diagnosis in primary care: population-based observational study in England, Age and Ageing, , afy194, is available online at: https://dx.doi.org/10.1093/ageing/afy194
Sponsor
National Institute for Health Research
Dr Foster Intelligence
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/30624588
PII: 5281111
Grant Number
n/a
WPPA_P72388
Subjects
Science & Technology
Life Sciences & Biomedicine
Geriatrics & Gerontology
heart failure
emergency hospitalisation
frailty
CPRD
older people
CLINICAL-TRIALS
RISK
READMISSION
VALIDATION
MORTALITY
MODELS
CPRD
emergency hospitalisation
frailty
heart failure
older people
Geriatrics
1103 Clinical Sciences
1701 Psychology
1117 Public Health and Health Services
Publication Status
Published
Coverage Spatial
England
Article Number
afy194
Date Publish Online
2019-01-09