Increased Peptide YY blood concentrations, not decreased acyl-ghrelin, are associated with reduced hunger and food intake in healthy older women: preliminary evidence
File(s)
Author(s)
Hickson, M
Frost, G
Dhillo, WS
Moss, C
Bottin, J
Type
Journal Article
Abstract
With ageing there is frequently a loss of appetite, termed anorexia of ageing, which can result in under-nutrition. We do not know how appetite control alters with ageing. The objective of this study was to investigate whether differences in the release of, and response to, gastrointestinal appetite hormones is altered in young compared to old healthy volunteers. We hypothesised that an increase in PYY and GLP-1 or a decrease ghrelin may result in a decreased appetite. A comparative experimental design, using a cross-sectional sample of ages from a healthy population, matched for sex and BMI was used. The study compared total ghrelin, acyl-ghrelin, PYY, GLP-1 and subjective appetite responses to ingestion of a standardised 2781kj (660kcal) test meal. 31 female volunteers aged between 21-92yrs took part. Multiple linear regression showed that both age and sex had an independent effect on energy intake. Subjective appetite scores showed that hunger, pleasantness to eat, and prospective food intake were significantly lower in the older age groups. PYY incremental area under the curve (IAUC) was greater in the oldest old compared to younger ages f(3,27)=2.9, p=0.05. No differences in GLP-1, ghrelin or acyl-ghrelin were observed in the older compared to younger age groups. Our data suggest that there may be increases in postprandial PYY(3-36) levels in female octogenarians, potentially resulting in reduced appetite. There does not appear to be any change in ghrelin or acyl-ghrelin concentrations with ageing.
Date Issued
2016-06-03
Date Acceptance
2016-06-01
Citation
Appetite, 2016, 105, pp.320-327
ISSN
1095-8304
Publisher
Elsevier
Start Page
320
End Page
327
Journal / Book Title
Appetite
Volume
105
Copyright Statement
© 2016, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor
Imperial College Healthcare Charity
National Institute for Health Research
National Institute for Health Research
Grant Number
DDMH_P20024
RDA05 79560
RP-2014-05-001
Subjects
Ageing
Anorexia
Appetite
Ghrelin
PYY
Nutrition & Dietetics
MD Multidisciplinary
Publication Status
Published