Cellular immune activity biomarker neopterin is associated hyperlipidemia: results from a large population-based study
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Published version
Author(s)
Type
Journal Article
Abstract
Background
Increased serum neopterin had been described in older age two decades ago. Neopterin is a biomarker of systemic adaptive immune activation that could be potentially implicated in metabolic syndrome (MetS). Measurements of waist circumference, triglycerides, high-density lipoprotein cholesterol (HDLC), systolic and diastolic blood pressure, glycated hemoglobin as components of MetS definition, and plasma total neopterin concentrations were performed in 594 participants recruited in the European Prospective Investigation into Cancer and Nutrition (EPIC).
Results
Higher total neopterin concentrations were associated with reduced HDLC (9.7 %, p < 0.01 for men and 9.2 %, p < 0.01 for women), whereas no association was observed with the rest of the MetS components as well as with MetS overall (per 10 nmol/L: OR = 1.42, 95 % CI = 0.85-2.39 for men and OR = 1.38, 95 % CI = 0.79-2.43).
Conclusions
These data suggest that high total neopterin concentrations are cross-sectionally associated with reduced HDLC, but not with overall MetS.
Increased serum neopterin had been described in older age two decades ago. Neopterin is a biomarker of systemic adaptive immune activation that could be potentially implicated in metabolic syndrome (MetS). Measurements of waist circumference, triglycerides, high-density lipoprotein cholesterol (HDLC), systolic and diastolic blood pressure, glycated hemoglobin as components of MetS definition, and plasma total neopterin concentrations were performed in 594 participants recruited in the European Prospective Investigation into Cancer and Nutrition (EPIC).
Results
Higher total neopterin concentrations were associated with reduced HDLC (9.7 %, p < 0.01 for men and 9.2 %, p < 0.01 for women), whereas no association was observed with the rest of the MetS components as well as with MetS overall (per 10 nmol/L: OR = 1.42, 95 % CI = 0.85-2.39 for men and OR = 1.38, 95 % CI = 0.79-2.43).
Conclusions
These data suggest that high total neopterin concentrations are cross-sectionally associated with reduced HDLC, but not with overall MetS.
Date Issued
2016-02-25
Date Acceptance
2016-02-05
Citation
Immunity & Ageing, 2016, 13
ISSN
1742-4933
Publisher
BioMed Central
Journal / Book Title
Immunity & Ageing
Volume
13
Copyright Statement
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Sponsor
University Medical Center Utrecht
Imperial College Trust
Grant Number
N/A
P47328
Subjects
Science & Technology
Life Sciences & Biomedicine
Geriatrics & Gerontology
Immunology
Neopterin
Cell-mediated immunity
Metabolic syndrome
CORONARY-ARTERY-DISEASE
COLORECTAL-CANCER RISK
ADVERSE CARDIAC EVENTS
SERUM NEOPTERIN
INTERFERON-GAMMA
METABOLIC SYNDROME
SYSTEM ACTIVATION
HORDALAND HEALTH
GENETIC-VARIANTS
PROGNOSTIC VALUE
1103 Clinical Sciences
1107 Immunology
Publication Status
Published
Article Number
5