Plasma S100A8/A9 heterodimer is an early prognostic marker of acute kidney injury associated with cardiac surgery
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Published version
Author(s)
Nikolakopoulou, Zacharoula
Hector, Lauren R
Creagh-Brown, Benedict C
Evans, Timothy
Quinlan, Gregory
Type
Journal Article
Abstract
We investigated whether plasma levels of the inflammation marker S100A8/A9, could predict acute
kidney injury (AKI) onset in patients undergoing cardiac surgery necessitating cardiopulmonary bypass
(CPB). Patients & methods: Plasma levels of S100A8/A9 and other neutrophil cytosolic proteins were measured in 39 patients pre- and immediately post-CPB. Results: All markers increased significantly post-CPB
with S100A8/A9, S100A12 and myeloperoxidase levels significantly higher in patients who developed AKI
within 7 days. S100A8/A9 had good prognostic utility for AKI, with an area under the receiver operating characteristic curve of 0.81 (95% CI: 0.676–0.949) and a cut-off value of 10.6 μg/ml (85.7% sensitivity
and 75% specificity) irrespective of age. Conclusion: Plasma S100A8/A9 levels immediately after cardiac
surgery, can predict onset of AKI, irrespective of age.
kidney injury (AKI) onset in patients undergoing cardiac surgery necessitating cardiopulmonary bypass
(CPB). Patients & methods: Plasma levels of S100A8/A9 and other neutrophil cytosolic proteins were measured in 39 patients pre- and immediately post-CPB. Results: All markers increased significantly post-CPB
with S100A8/A9, S100A12 and myeloperoxidase levels significantly higher in patients who developed AKI
within 7 days. S100A8/A9 had good prognostic utility for AKI, with an area under the receiver operating characteristic curve of 0.81 (95% CI: 0.676–0.949) and a cut-off value of 10.6 μg/ml (85.7% sensitivity
and 75% specificity) irrespective of age. Conclusion: Plasma S100A8/A9 levels immediately after cardiac
surgery, can predict onset of AKI, irrespective of age.
Date Issued
2019-02-01
Date Acceptance
2018-12-10
Citation
Biomarkers in Medicine, 2019, 13 (3), pp.205-218
ISSN
1752-0363
Publisher
Future Medicine
Start Page
205
End Page
218
Journal / Book Title
Biomarkers in Medicine
Volume
13
Issue
3
Copyright Statement
© 2018 The Authors. This work is licensed under the Attribution-NonCommercial-NoDerivatives 4.0 Unported License. To view a copy of this license,
visit http://creativecommons.org/licenses/by-nc-nd/4.0/.
visit http://creativecommons.org/licenses/by-nc-nd/4.0/.
Sponsor
Dunhill Medical Trust
Grant Number
R421E/1114
Subjects
Science & Technology
Life Sciences & Biomedicine
Medicine, Research & Experimental
Research & Experimental Medicine
CELL-FREE DNA
INFLAMMATORY RESPONSES
CARDIOPULMONARY BYPASS
URINARY CALPROTECTIN
HUMAN S100A12
ACTIVATION
DISEASE
PROTEIN
EXPRESSION
BIOMARKERS
Oncology & Carcinogenesis
Publication Status
Published
Date Publish Online
2019-02-27