Regulation of energy expenditure and substrate oxidation by short chain fatty acids
File(s)
Accepted version
Author(s)
Sukkar, Alia
Lett, Aaron
Frost, Gary
Chambers, Edward
Type
Journal Article
Abstract
Short-chain fatty acids (SCFAs) are metabolites produced from the fermentation of dietary fibre by the gut microbiota. High-fibre diets have been associated with lower weight gain and a number of reports have therefore investigated if these positive effects of a dietary fibre on body weight can be replicated through the direct administration of SCFAs. Many of these studies have reported that SCFAs can prevent or attenuate long-term body weight gain by increasing energy expenditure through increased lipid oxidation. The aim of the present review is to therefore evaluate the current evidence for an effect of SCFAs on whole-body energy expenditure and to assess the potential underlying mechanisms. The available data highlights that SCFAs can exert multiple effects at various organ and tissue sites that would cumulatively raise energy expenditure via a promotion of lipid oxidation. In conclusion, the present review proposes that dietary interventions and other therapies that augment gut-derived SCFAs and systemic availability may present an effective strategy to improve long-term energy balance and body weight management.
Date Issued
2019-08-01
Date Acceptance
2019-05-01
Citation
Journal of Endocrinology, 2019, 242 (2), pp.R1-R8
ISSN
1479-6805
Publisher
BioScientifica
Start Page
R1
End Page
R8
Journal / Book Title
Journal of Endocrinology
Volume
242
Issue
2
Copyright Statement
© 2019 Society for Endocrinology. Published by Bioscientifica Ltd.
Subjects
Endocrinology & Metabolism
1103 Clinical Sciences
0707 Veterinary Sciences
0702 Animal Production
Publication Status
Published
Date Publish Online
2019-05-01