Association between sucrose intake and risk of overweight and obesity in a prospective sub-cohort of the European Prospective Investigation into Cancer in Norfolk (EPIC-Norfolk).
Author(s)
Type
Journal Article
Abstract
OBJECTIVE: The objective of the present study was to investigate associations between sugar intake and overweight using dietary biomarkers in the Norfolk cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Norfolk). DESIGN: Prospective cohort study. SETTING: EPIC-Norfolk in the UK, recruitment between 1993 and 1997. SUBJECTS: Men and women (n 1734) aged 39-77 years. Sucrose intake was assessed using 7 d diet diaries. Baseline spot urine samples were analysed for sucrose by GC-MS. Sucrose concentration adjusted by specific gravity was used as a biomarker for intake. Regression analyses were used to investigate associations between sucrose intake and risk of BMI>25·0 kg/m2 after three years of follow-up. RESULTS: After three years of follow-up, mean BMI was 26·8 kg/m2. Self-reported sucrose intake was significantly positively associated with the biomarker. Associations between the biomarker and BMI were positive (β=0·25; 95 % CI 0·08, 0·43), while they were inverse when using self-reported dietary data (β=-1·40; 95 % CI -1·81, -0·99). The age- and sex-adjusted OR for BMI>25·0 kg/m2 in participants in the fifth v. first quintile was 1·54 (95 % CI 1·12, 2·12; P trend=0·003) when using biomarker and 0·56 (95 % CI 0·40, 0·77; P trend<0·001) with self-reported dietary data. CONCLUSIONS: Our results suggest that sucrose measured by objective biomarker but not self-reported sucrose intake is positively associated with BMI. Future studies should consider the use of objective biomarkers of sucrose intake.
Date Issued
2015-10
Date Acceptance
2015-01-21
Citation
Public Health Nutrition, 2015, 18 (15), pp.2815-2824
ISSN
1368-9800
Publisher
Cambridge University Press
Start Page
2815
End Page
2824
Journal / Book Title
Public Health Nutrition
Volume
18
Issue
15
Copyright Statement
© The Authors 2015. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://
creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original
work is properly cited.
creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original
work is properly cited.
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/25702697
PII: S1368980015000300
Subjects
Biomarker
Obesity
Sugar
Adult
Aged
Biomarkers
Body Mass Index
Diet
Diet Records
Dietary Sucrose
England
Europe
Feeding Behavior
Female
Humans
Male
Middle Aged
Neoplasms
Nutritional Status
Obesity
Odds Ratio
Overweight
Prospective Studies
Risk Factors
Self Report
Publication Status
Published
Coverage Spatial
England
Date Publish Online
2015-02-23