Gold nanodoughnut as an outstanding nanoheater for photothermal applications
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Published version
Author(s)
Type
Journal Article
Abstract
Photoinduced hyperthermia is a cancer therapy technique that induces death to cancerous cells via heat generated by plasmonic nanoparticles. While previous studies have shown that some nanoparticles can be effective at killing cancer cells under certain conditions, there is still a necessity (or the need) to improve its heating efficiency. In this work, we perform a detailed theoretical study comparing the thermoplasmonic response of the most effective nanoparticle geometries up to now with a doughnut-shaped nanoparticle. We numerically demonstrate that the latter exhibits a superior tunable photothermal response in practical illumination conditions (unpolarized light). Furthermore, we show that nanoparticle heating in fluidic environments, i.e., nanoparticles undergoing Brownian rotations, strongly depends on the particle orientation with respect to the illumination source. We conclude that nanodoughnuts are the best nanoheaters in our set of structures, with an average temperature increment 40% higher than the second best nanoheater (nanodisk). Furthermore, nanodoughnuts feature a weak dependence on orientation, being therefore ideal candidates for photothermal therapy applications. Finally, we present a designing guide, covering a wide range of toroid designs, which can help on its experimental implementation.
Date Issued
2022-01-03
Date Acceptance
2021-11-22
Citation
Optics Express, 2022, 30 (1), pp.125-137
ISSN
1094-4087
Publisher
Optical Society of America (OSA)
Start Page
125
End Page
137
Journal / Book Title
Optics Express
Volume
30
Issue
1
Copyright Statement
© 2022. Published by Optica Publishing Group under the terms of the Creative Commons Attribution 4.0 License. Further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation, and DOI.
License URL
Sponsor
The Leverhulme Trust
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000738278500011&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Grant Number
RPG-2018-384
Subjects
Science & Technology
Physical Sciences
Optics
CANCER-THERAPY
NANOPARTICLES
ABLATION
TUMORS
NANORODS
HYPERTHERMIA
FABRICATION
GENERATION
HEAT
Publication Status
Published
Article Number
ARTN 446637
Date Publish Online
2021-12-20