The peptide-binding cavity Is essential for Als3-mediated adhesion of Candida albicans to human cells
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
Background: Of the eight cell surface glycoproteins in the C. albicans Als family, Als3 makes the largest contribution to adhesion to human cells.
Results: Mutation of the Als3 peptide-binding cavity (PBC) results in loss of Als3 adhesive function.
Conclusion: The PBC is required for Als3 adhesive function.
Significance: Interfering with PBC function is a viable strategy for inhibiting C. albicans adhesion.
Results: Mutation of the Als3 peptide-binding cavity (PBC) results in loss of Als3 adhesive function.
Conclusion: The PBC is required for Als3 adhesive function.
Significance: Interfering with PBC function is a viable strategy for inhibiting C. albicans adhesion.
Date Issued
2014-06-27
Date Acceptance
2014-05-06
Citation
Journal of Biological Chemistry, 2014, 289 (26), pp.18401-18412
ISSN
1083-351X
Publisher
American Society for Biochemistry and Molecular Biology
Start Page
18401
End Page
18412
Journal / Book Title
Journal of Biological Chemistry
Volume
289
Issue
26
Copyright Statement
© 2014 by The American Society for Biochemistry and Molecular Biology, Inc. Free via Creative Commons: CC-BY license
License URL
Sponsor
Wellcome Trust
Biotechnology and Biological Sciences Research Council (BBSRC)
Grant Number
085464/Z/08/Z
BB/K003887/1
Subjects
Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
BIOCHEMISTRY & MOLECULAR BIOLOGY
BIOFILM FORMATION
ALS FAMILY
PROTEIN
GENE
EPIDEMIOLOGY
SPECIFICITY
SEQUENCE
SURVEILLANCE
LIGANDS
Publication Status
Published
Date Publish Online
2021-01-04